Results 51 to 60 of about 182,452 (358)

Approche intégrée des maladies émergentes à transmission vectorielle et changements mondiaux : exemple et perspective [PDF]

, 2009
Vector-borne diseases (e.g., bluetongue or Rift Valley fever) are very sensitive to environmental changes. As such, they are excellent models to study disease emergence in a changing world, with more intense commercial exchanges, climate changes, and ...
Aumont, Gilles, De La Rocque, Stéphane, Gouro, Abdoulaye, Lancelot, Renaud   +3 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Species abundance, composition, and nocturnal activity of female Anopheles (Diptera: Culicidae) in malaria-endemic villages of Papua New Guinea: assessment with barrier screen sampling

Malaria Journal, 2019
Background Community composition of Anopheles mosquitoes, and their host-seeking and peridomestic behaviour, are important factors affecting malaria transmission.
John B. Keven, Michelle Katusele, Rebecca Vinit, Gussy Koimbu, Naomi Vincent, Edward K. Thomsen, Stephan Karl, Lisa J. Reimer, Edward D. Walker   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Genomic Evaluation of the Genus Coltivirus Indicates Genetic Diversity among Colorado Tick Fever Virus Strains and Demarcation of a New Species

Diseases, 2021
The type species of the genus Coltivirus, Colorado tick fever virus (CTFV), was discovered in 1943 and is the most common tick-borne viral infection in the Western US.
Holly R. Hughes, Jason O. Velez, Kelly Fitzpatrick, Emily H. Davis, Brandy J. Russell, Amy J. Lambert, J. Erin Staples, Aaron C. Brault   +7 more
doaj   +1 more source

The Influence of Climate Change on Disease and Public Health [PDF]

, 2020
This paper attempts to analyze the growing influence of climate change on the spread and development of diseases, as well as how this continues to affect public health and medical administrations around the world.
Petruzelli, Natalie
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Optimizing identification of Lyme disease diagnoses in commercial insurance claims data, United States, 2016–2019

BMC Infectious Diseases
Background Commercial insurance claims data are a stable and consistent source of information on Lyme disease diagnoses in the United States and can contribute to our understanding of overall disease burden and the tracking of epidemiological trends ...
Courtney C. Nawrocki, Austin R. Earley, Sarah A. Hook, Alison F. Hinckley, Kiersten J. Kugeler   +4 more
doaj   +1 more source

The phenology and population dynamics of Culicoides spp. in different ecosystems in the Netherlands [PDF]

, 2008
The Netherlands has enjoyed a relatively free state of vector-borne diseases of economic importance for more than one century. Emerging infectious diseases may change this situation, threatening the health of humans, domestic livestock and wildlife.
Jacobs, F.H.H., Jongema, Y., Lammeren, R.J.A., van, Scholte, E.J., Takken, W., Verhulst, N.O.   +5 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source