Results 101 to 110 of about 217,155 (332)
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
A Geometric characterization of Finsler manifolds of constant curvature K=1
International Journal of Mathematics and Mathematical Sciences, 2000 We prove that a Finsler manifold 𝔽m is of constant curvature K=1 if and only if the unit horizontal Liouville vector field is a Killing vector field on the indicatrix bundle IM of 𝔽m.
A. Bejancu, H. R. Farran
doaj +1 more source
Algebraic & Geometric TopologyWe define a turning of a rank-$2k$ vector bundle $E \to B$ to be a homotopy of bundle automorphisms $ψ_t$ from $\mathbb{Id}_E$, the identity of $E$, to $-\mathbb{Id}_E$, minus the identity, and call a pair $(E, ψ_t)$ a turned bundle. We investigate when vector bundles admit turnings and develop the theory of turnings and their obstructions.
Crowley, Diarmuid +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Elliptic operators on refined Sobolev scales on vector bundles
Open Mathematics, 2017 We introduce a refined Sobolev scale on a vector bundle over a closed infinitely smooth manifold. This scale consists of inner product Hörmander spaces parametrized with a real number and a function varying slowly at infinity in the sense of Karamata. We
Zinchenko Tetiana
doaj +1 more source
Lelong Numbers and Vector Bundles [PDF]
The Journal of Geometric Analysis, 2017 Abstract We study Lelong numbers and integrability indices for $$S^1$$ S 1 -invariant singular metrics on vector bundles over the disk.
openaire +3 more sources
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
International Mathematics Research NoticesAbstract We introduce higher analogs for cleavages in the context of (Kan) simplicial fibrations. We apply them to obtain geometric models for representations up to homotopy of (higher) Lie groupoids. Concretely, we set an equivalence between representations up to homotopy and simplicial vector bundles endowed with a cleavage. Our result
del Hoyo, Matias, Trentinaglia, Giorgio
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Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source