Results 101 to 110 of about 1,003,393 (301)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Discovery of new antigens for serodiagnosis of visceral leishmaniasis in humans and dogs adds valuable tools to our arsenal

mBio
Surveillance and sustained control of visceral leishmaniasis (VL) require reliable serodiagnostic tools. rK39, the gold standard antigen for VL diagnosis, is limited by its documented poor sensitivity in certain endemic regions, such as East Africa, and ...
Eva Iniguez, Shaden Kamhawi
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Phylogenetic Stochastic Mapping without Matrix Exponentiation

, 2014
Phylogenetic stochastic mapping is a method for reconstructing the history of trait changes on a phylogenetic tree relating species/organisms carrying the trait. State-of-the-art methods assume that the trait evolves according to a continuous-time Markov
Irvahn, Jan, Minin, Vladimir N.
core   +1 more source

Outcome of capacity building intervention for malaria vector surveillance, control and research in Nigerian higher institutions

Malaria Journal, 2018
Background Despite the availability of effective malaria vector control intervention tools, implementation of control programmes in Nigeria is challenged by inadequate entomological surveillance data.
Adedayo O. Oduola, Abiodun Obembe, Olukayode J. Adelaja, Adeniyi K. Adeneye, Joel Akilah, Taiwo S. Awolola   +5 more
doaj   +1 more source

Current Communications in Molecular Biology: Viral Vectors. Edited by Yakov Gluzman and Stephen H. Hughes. New York: Cold Spring Harbor Laboratory. 1988. 180 pages. Paper $20.00. [PDF]

, 1989
Julian F. Burke
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Comparative mitogenome research revealed the phylogenetics and evolution of the superfamily Tenebrionoidea (Coleoptera: Polyphage)

Ecology and Evolution
Despite the worldwide distribution and rich diversity of the superfamily Tenebrionoidea, the knowledge of the mitochondrial genomes (mtgenome) characteristics of the superfamily is still very limited, and its phylogenetics and evolution remain unresolved.
Yun‐Jian Hu, Feng‐Fan Jia, Li Hu, Chuan Wu, Tian Tian, Ting‐Jing Li, Bin Chen   +6 more
doaj   +1 more source

RNAi-Mediated Knockdown of Acidic Ribosomal Stalk Protein P1 Arrests Egg Development in Adult Female Yellow Fever Mosquitoes, Aedes aegypti

Insects
After taking a blood meal, the fat body of the adult female yellow fever mosquito, Aedes aegypti, switches from a previtellogenic state of arrest to an active state of synthesizing large quantities of yolk protein precursors (YPPs) that are crucial for ...
Mahesh Lamsal, Hailey A. Luker, Matthew Pinch, Immo A. Hansen   +3 more
doaj   +1 more source

A defined subunit vaccine that protects against vector-borne visceral leishmaniasis

npj Vaccines, 2017
Leishmaniasis: Improved vaccine candidate demonstrates protection A research collaboration between the United States and Bangladesh has improved its own vaccine candidate and demonstrated it to be effective.
Malcolm S. Duthie, Lais Pereira, Michelle Favila, Kimberly A. Hofmeyer, S. Jim Reed, Sonia Metangmo, Shannon Townsend, John D. Laurance, Alessandro Picone, Ayesha Misquith, Faria Hossain, Prakash Ghosh, Md Anik Ashfaq Khan, Jeffery Guderian, H. Remy Bailor, Hong Liang, Julie Vergara, Fabiano Oliveira, Randall F. Howard, Shaden Kamhawi, Dinesh Mondal, Rhea N. Coler, Jesus G. Valenzuela, Steven G. Reed   +23 more
doaj   +1 more source