Results 51 to 60 of about 946,872 (311)

A topological approach for protein classification

, 2015
Protein function and dynamics are closely related to its sequence and structure. However prediction of protein function and dynamics from its sequence and structure is still a fundamental challenge in molecular biology.
Cang, Zixuan, Mu, Lin, Opron, Kristopher, Wei, Guo-Wei, Wu, Kedi, Xia, Kelin   +5 more
core   +1 more source

Extraction of Transcript Diversity from Scientific Literature [PDF]

, 2005
Transcript diversity generated by alternative splicing and associated mechanisms contributes heavily to the functional complexity of biological systems.
Lars J Jensen, Parantu K Shah, Peer Bork, Philip Bourne, Stéphanie Boué   +4 more
core   +6 more sources

Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis

npj Vaccines, 2022
Leishmaniasis is one of the top neglected tropical diseases with significant morbidity and mortality in low and middle-income countries (LMIC). However, this disease is also spreading in the developed world.
Subir Karmakar, Greta Volpedo, Wen-Wei Zhang, Patrick Lypaczewski, Nevien Ismail, Fabiano Oliveira, James Oristian, Claudio Meneses, Sreenivas Gannavaram, Shaden Kamhawi, Shinjiro Hamano, Jesus G. Valenzuela, Greg Matlashewski, Abhay R. Satoskar, Ranadhir Dey, Hira L. Nakhasi   +15 more
doaj   +1 more source

Molecular biology on a microfluidic chip [PDF]

, 2006
We have developed microfluidic chips for automating molecular biology processes such as gene ligation and gene transformation from nanolitre sample volumes with parallel architecture. Unlike conventional tube methods with cumbersome pipetting procedures,
Anderson, W. French, Chen, Yan, Hong, Jong Wook, Quake, Stephen R.   +3 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. [PDF]

, 2014
Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon ...
Beckerle, Mary C, Chaturvedi, Aashi, Grossmann, Allie H, Hoffman, Laura M, Jensen, Christopher C, Lessnick, Stephen L, Lin, Yi-Chun, Randall, R Lor, Welm, Alana L   +8 more
core   +1 more source

The complete mt genomes of Lutzia halifaxia, Lt. fuscanus and Culex pallidothorax (Diptera: Culicidae) and comparative analysis of 16 Culex and Lutzia mt genome sequences

Parasites & Vectors, 2019
Background Despite the medical importance of the genus Culex, the mitochondrial genome (mt genome) characteristics of Culex spp. are not well understood.
Ling Sun, Ting-Jing Li, Wen-Bo Fu, Zhen-Tian Yan, Feng-Ling Si, Yu-Juan Zhang, Qi-Meng Mao, Bruna Demari-Silva, Bin Chen   +8 more
doaj   +1 more source

Allelic diversity of merozoite surface protein genes (msp1 and msp2) and clinical manifestations of Plasmodium falciparum malaria cases in Aceh, Indonesia

Malaria Journal, 2021
Background The malaria control programme in Indonesia has successfully brought down malaria incidence in many parts in Indonesia, including Aceh Province.
Kurnia Fitri Jamil, Nandha Rizki Pratama, Sylvia Sance Marantina, Harapan Harapan, Muhammad Riza Kurniawan, Tjut Mariam Zanaria, Jontari Hutagalung, Ismail Ekoprayitno Rozi, Puji Budi Setia Asih, Supargiyono, Din Syafruddin   +10 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source