Results 81 to 90 of about 946,872 (311)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

VectorBase: improvements to a bioinformatics resource for invertebrate vector genomics. [PDF]

, 2011
VectorBase (http://www.vectorbase.org) is a NIAID-supported bioinformatics resource for invertebrate vectors of human pathogens. It hosts data for nine genomes: mosquitoes (three Anopheles gambiae genomes, Aedes aegypti and Culex quinquefasciatus), tick (
Campbell, David, Dialynas, Emmanuel, Emrich, Scott J, Hughes, Daniel ST, Koscielny, Gautier, Lawson, Daniel, Louis, Christos, Maccallum, Robert M, Megy, Karine, Redmond, Seth N, Sheehan, Andrew, Topalis, Pantelis, VectorBase Consortium, Wilson, Derek   +13 more
core   +5 more sources

Leishmania sand fly-transmission is disrupted by Delftia tsuruhatensis TC1 bacteria

Nature Communications
Most human pathogenic Leishmania species are zoonotic agents; therefore, sand fly-based control strategies are essential to prevent parasite circulation.
Pedro Cecilio, Luana A. Rogerio, Tiago D. Serafim, Kristina Tang, Laura Willen, Eva Iniguez, Claudio Meneses, Luis F. Chaves, Yue Zhang, Luiza dos Santos Felix, Wei Huang, Melina Garcia Guizzo, Pablo Castañeda-Casado, Marcelo Jacobs-Lorena, Jesus G. Valenzuela, Janneth Rodrigues, Fabiano Oliveira   +16 more
doaj   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Transgenic resistance to PMTV and PVA provides novel insights to viral long-distance movement [PDF]

, 2005
The studies in this thesis describe forms of transgenic resistance to plant viruses and how they can be used for studying viral infection cycle. S. tuberosum cv.
Germundsson, Anna
core  

Physical constraints on accuracy and persistence during breast cancer cell chemotaxis [PDF]

, 2019
Directed cell motion in response to an external chemical gradient occurs in many biological phenomena such as wound healing, angiogenesis, and cancer metastasis.
Han, Bumsoo, Moon, Hye-ran, Mugler, Andrew, Saha, Soutick, Varennes, Julien   +4 more
core   +4 more sources

Salivary antigens rPagSP02 and rPagSP06 are a reliable composite biomarker for evaluating exposure to Phlebotomus argentipes in Sri Lanka

Scientific Reports
Phlebotomus argentipes is the established vector of leishmaniasis in the Indian sub-continent. Antibodies to sand fly salivary antigens are biomarkers for vector-host exposure in leishmaniasis-endemic regions. Ph. argentipes transmits Leishmania donovani
Sachee Bhanu Piyasiri, Sanath Senanayake, Nilakshi Smaranayake, Serena Doh, Eva Iniguez, Jesus Gilberto Valenzuela, Shaden Kamhawi, Nadira Darshani Karunaweera   +7 more
doaj   +1 more source

Transcriptomic analysis of resistance and short-term induction response to pyrethroids, in Anopheles coluzzii legs

BMC Genomics, 2021
Background Insecticide-treated bed nets and indoor residual spraying comprise the major control measures against Anopheles gambiae sl, the dominant vector in sub-Saharan Africa. The primary site of contact with insecticide is through the mosquitoes’ legs,
M. Kefi, J. Charamis, V. Balabanidou, P. Ioannidis, H. Ranson, V. A. Ingham, J. Vontas   +6 more
doaj   +1 more source

Advanced RNA synthesis as a key tool in RNA biology research [PDF]

Journal of Stem Cell Research & Therapy, 2015
Background. The aim of the study was to assess the histological effects of autologous infusion of adipose‐derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We used 74 New Zealand rabbits. Sixteen of them were used
Angelou Valerie, Kalodimou Vassiliki, Messini Irini, Psychalakis Nikolaos, Eleftheria Karampela, Papalois Apostolos   +5 more
openaire   +28 more sources