Results 111 to 120 of about 36,083 (304)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Influence of parameters detuning on induction motor NFO shaft-sensorless scheme
Advances in Electrical and Computer Engineering, 2010 In this paper, the parameter sensitivity analysis of shaft-sensorless induction motor drive with natural field orientation (NFO) scheme is performed. NFO scheme calculates rotor flux position using the rotor flux vector reference only, does not require
KULIC, F. +3 more
doaj +1 more source
Designing Anti-islanding Detection Using the Synchrophasor Vector Processor
, 2013 Designing Anti-Islanding Detection Using the Synchrophasor Vector Processor Ruth Huang The need for distributed generation (DG) has become more and more popular because of the adverse effects of fossil fuels and the fear of running out of fossil fuels ...
Huang, Ruth Christiana
core +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Vector processing as a soft-core processor accelerator
, 2008 Soft processors simplify hardware design by being able to implement complex control strategies using software. However, they are not fast enough for many intensive data-processing tasks, such as highly data-parallel embedded applications.
Yu, Jason Kwok Kwun
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Vector Controlled Delay Cell with Nearly Identical Rise/Fall Time for Processor Clock Application [PDF]
Informacije MIDEM, 2021 P. Bhattacharjee +2 more
doaj +1 more source