Results 111 to 120 of about 22,809 (305)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Transaction Level Model of Embedded Processor for Vector-Logical Analysis

, 2012
Transaction level model of embedded processor for improving the performance of logical relation analysis are proposed. It is based on the hardware implementation of vector operations.
Adamov, A., Hahanova, I. V., Shcherbin, D., Obrizan, V.   +3 more
core  

An Open-source Framework for the Generation of RISC-V Processor + CGRA Accelerator Systems

, 2021
Course-Grained Recongurable Architectures (CGRAs) are programmable hardware devices containing coarse-grained processing elements that can perform ALU-like functions and having word-wide programmable interconnect.
Ling, Xiaoyi
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Vocabulary Forest Object Matching Processor With 2.07 M-Vector/s Throughput and 13.3 nJ/Vector Per-Vector Energy for Full-HD 60 fps Video Object Recognition

, 2015
Approximate nearest neighbor searching has been studied as the keypoint matching algorithm for object recognition systems, and its hardware realization has reduced the external memory access which is the main bottleneck in object recognition process ...
Kim, Gyeonghoon, Park, Junyoung, Lee, Kyuho Jason, Yoo, Hoi-Jun   +3 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Hard Real-Time Kernel for CPIoT Systems With Safety Features in Rust

IEEE Access
The increasing deployment of Cyber-Physical Internet of Things (CPIoT) systems in safety-critical domains demands execution environments with strict real-time guarantees, memory safety, and high reliability.
Nayancy Gupta, Gourinath Banda, Neminath Hubballi, K. V. Srinivas   +3 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A comprehensive construction of deep neural network‐based encoder–decoder framework for automatic image captioning systems

IET Image Processing
This study introduces a novel encoder–decoder framework based on deep neural networks and provides a thorough investigation into the field of automatic picture captioning systems.
Md Mijanur Rahman, Ashik Uzzaman, Sadia Islam Sami, Fatema Khatun, Md Al‐Amin Bhuiyan   +4 more
doaj   +1 more source

On the power of parallel machines with high-arity instruction sets [PDF]

We consider various models of parallel computers based on communication networks of sequential processors. The degree of a parallel machine is the number of communication lines connected Lo each processor; the arity is the number of these lines which a ...
Parberry, Ian
core