Results 131 to 140 of about 22,809 (305)

Vector-supercomputers

, 1988
Today, the field of high-speed computers and supercomputing applications is dominated by the vector-processor architecture. This paper gives a survey on the architectural principles of vector computers like segmentation, pipelining, and chaining as well ...
Hossfeld, Friedel
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Novel Physics-Informed Bayesian Fusion Post-Processor for Enhanced Gait Phase Recognition Using Surface Electromyography

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Myoelectric pattern recognition systems serve as a promising predictive control approach for the lower limbs prostheses and exoskeletons. However, their actual deployment is challenged by the signal stochastic nature that could contaminate the decision ...
Rami Mobarak, Alessandro Mengarelli, Rami N. Khushaba, Ali H. Al-Timemy, Federica Verdini, Sandro Fioretti, Laura Burattini, Andrea Tigrini   +7 more
doaj   +1 more source

Support-vector-machine based automatic performance modelling and optimisation for analogue and mixed-signal designs

, 2008
The growing popularity of analogue and mixed-signal (AMS) ASIC and SoC designs for communication applications has led to an increasing requirement for high efficiency performance modelling and optimisation methodologies in AMS synthesis systems. Recently,
Ren, Xianqiang
core  

Vector Processing in NUMA Systems

, 2023
Over the last decade, applications like self-driving, image recognition and speech processing are having more and more impact on the society, all these applications are based on machine learning, and machine learning is all about metrics and vectors. For
Hu, Zhewen (author)
core  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Hardware-Agnostic Quantum Kernel Feature Mapping for Anomaly Detection in Critical Infrastructure: A Cross-Testbed Validation on NISQ Processors

IEEE Access
Modern Industrial Control Systems (ICS) face sophisticated cyber-physical attacks that exploit nonlinear correlations between process variables, rendering traditional linear classifiers ineffective. This paper presents a hardware-agnostic Quantum Support
Shujaatali Badami
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source