Results 71 to 80 of about 21,846 (260)

Unveiling clean two-dimensional discrete time crystals on a digital quantum computer

npj Quantum Information
Periodically driven (Floquet) many-body systems tend to absorb energy and approach an infinite-temperature state, yet can host emergent order such as discrete time crystals (DTCs).
Kazuya Shinjo, Kazuhiro Seki, Tomonori Shirakawa, Rong-Yang Sun, Seiji Yunoki   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Microwave Photonic 2 × 2 IBFD–MIMO Communication System with Narrowband Self-Interference Cancellation

Micromachines
Combined in-band full duplex-multiple input multiple output (IBFD–MIMO) technology can significantly improve spectrum efficiency and data throughput, and has broad application prospects in communications, radar, the Internet of Things (IoT), and other ...
Ying Ma, Fangjing Shi, Yangyu Fan
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

General Architecture and Instruction Set Enhancements for Multimedia Applications [PDF]

Journal of Systemics, Cybernetics and Informatics, 2007
The present day multimedia applications (MMAs) are driving the computing industry as every application being developed is using multimedia in one or the other way.
Mansour Assaf, Aparna Rajesh
doaj  

Minimal approach to neuro-inspired information processing

Frontiers in Computational Neuroscience, 2015
To learn and mimic how the brain processes information has been a major research challenge for decades. Despite the efforts, little is known on how we encode, maintain and retrieve our memories.
Miguel C. Soriano, Daniel eBrunner, Miguel eEscalona-Moran, Claudio R. Mirasso, Ingo eFischer   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Fuzzy-2 deployment in indirect vector control and hybrid space vector modulation for a two-level inverter fed induction motor drive

Scientific Reports
Soft computing based expert systems have a pivotal role to play in designing standalone mobility systems such as unmanned aerial vehicles. The expert systems are designed by learning from functional data of a system, thereby framing rules without relying
Abhiram Tikkani, Raghavendra Reddy Karasani, Kambhampati Venkata Govardhan Rao, CH Naga Sai Kalyan, B. Srikanth Goud, Mohit Bajaj, Milkias Berhanu Tuka   +6 more
doaj   +1 more source