Results 111 to 120 of about 21,719 (308)

Trading Vector Data in Vector Databases

CoRR
Vector data trading is essential for cross-domain learning with vector databases, yet it remains largely unexplored. We study this problem under online learning, where sellers face uncertain retrieval costs and buyers provide stochastic feedback to posted prices.
Jin Cheng 0008, Xiangxiang Dai, Ningning Ding, John C. S. Lui, Jianwei Huang 0001   +4 more
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Leptoconops bequaerti (Kieffer): un nuevo informe en la provincia de Santiago de Cuba

Medisan, 2014
Se realizó una investigación en la localidad de Sevilla, ubicada en el municipio costero de Guamá, en Santiago de Cuba, para identificar las especies de insectos causantes de molestias en esta población, así como sus principales fuentes de cría y los ...
Rosa María Castillo Quesada, Mirtha Gladys Pérez Menzies, Lino Robert Larrea Aguilera, Raúl González Broche, Daisy Figueredo Sánchez   +4 more
doaj  

Diversidad de chicharritas (Hemiptera: Cicadellidae) en el cultivo de maíz en Yucatán

AIA Avances en Investigación Agropecuaria
Objetivos. Evaluar la diversidad de chicharritas en dos sitios de la Península de Yucatán. Materiales y métodos. Se realizaron muestreos en cultivos de maíz en Xoy, municipio de Peto, y Uxmal, municipio de Muna en el mes de agosto de 2023 y 2024, en las
R. Daniel Suarez-Jiménez, Esaú Ruiz-Sánchez, Luis Latournerie-Moreno, Aldo D. Chan-Arjona, Horacio S. Ballina-Gómez, Jhibran Ferral Piña   +5 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Especies de cicadellidae (hemiptera: auchenorrhyncha) asociadas a gramíneas

AIA Avances en Investigación Agropecuaria
Introducción. Las especies de la familia Cicadellidae se caracterizan por su impacto directo (consumo de savia) e indirecto (transmisión de enfermedades) en los cultivos agrícolas.
Ana Monserrat Guzmán-Hernández, Aldo Daniel Chan-Arjona   +1 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Estado actual de la leishmaniosis en Costa Rica

Acta Médica Costarricense, 2009
Se realizó esta investigación, para conocer el comportamiento epidemiológico de esta enfermedad, los vectores relacionados y las especies de leishmanias causantes.
Orlando Jaramillo-Antillón, Azálea Espinoza-Aguirre, Raquel Lobo-Philp   +2 more
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source