Results 141 to 150 of about 21,719 (308)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Libro Mágico de Vectores con AR

, 2013
Se presenta la descripción y puesta en marcha de un libro tradicional de vectores 2D/3D, el cual ha sido extendido con contenido virtual. El resultado de la innovación educativa es llamado libro mágico de vectores, a través del cual los estudiantes ...
Palomino Ramírez, Luis, Falcón Morales, Luis E., Quezada Andrade, Juan C.   +2 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Cálculo vectorial en ℝ2. Vectores en el plano y en el espacio. Adición y multiplicación de un vector por un real. Segmentos dirigidos y vectores. Vectores paralelos. Producto escalar. Vectores ortogonales. Norma de un vector. Bases y proyección ortogonal de vectores en ℝ2. Ecuación vectorial de rectas en ℝ2. Resolución de problemas. Didáctica de los vectores en el plano

, 2019
La presente investigación monográfica titulada: Cálculo vectorial en ℝ2, muestra la importancia que tiene el estudio de los vectores en el plano y en el espacio;por tanto, partiendo desde la base de las coordenadas y la orientación,resultan ser útiles ...
Ponce Travezaño, Rocio del Carmen
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

[Environmental medicine and AI, migration, and emerging and reemerging diseases in Mexico]. [PDF]

Rev Med Inst Mex Seguro Soc
Rivera-Silva G, Moreno-Treviño MG, Garza-Martínez R.   +2 more
europepmc   +1 more source

Vectores y ficheros: servicio e-Licopter

, 2019
Mediante un ejemplo, se ilustra como leer y escribir en ficheros de texto, haciendo uso de vectores para completar lo pedido. Sólo se utiliza la función principal en el ejemplo.https://polimedia.upv.es/visor/?id=68baa010-7887-11e9-b19c-2d7bc55b9633Gil ...
Gil-Gómez, José-Antonio
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source