Results 81 to 90 of about 3,399 (266)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Leptoconops bequaerti (Kieffer): un nuevo informe en la provincia de Santiago de Cuba

Medisan, 2014
Se realizó una investigación en la localidad de Sevilla, ubicada en el municipio costero de Guamá, en Santiago de Cuba, para identificar las especies de insectos causantes de molestias en esta población, así como sus principales fuentes de cría y los ...
Rosa María Castillo Quesada, Mirtha Gladys Pérez Menzies, Lino Robert Larrea Aguilera, Raúl González Broche, Daisy Figueredo Sánchez   +4 more
doaj  

Conectando Puntos: Un Prototipo de Trabajo Práctico para Explorar la Ecuación de Continuidad

Revista Científica Ciencia y Tecnología
Este artículo presenta un estudio que tiene como objetivo demostrar la ecuación de continuidad en su forma diferencial e integral a través de un prototipo de trabajo práctico experimental.
Cliffor Jerry Herrera-Castrillo, Gretell Judith Zeledón Herrera, Kathering Amada Pérez Aguilar, Yirlanis Jaleska Laguna Laguna   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Diversidad de chicharritas (Hemiptera: Cicadellidae) en el cultivo de maíz en Yucatán

AIA Avances en Investigación Agropecuaria
Objetivos. Evaluar la diversidad de chicharritas en dos sitios de la Península de Yucatán. Materiales y métodos. Se realizaron muestreos en cultivos de maíz en Xoy, municipio de Peto, y Uxmal, municipio de Muna en el mes de agosto de 2023 y 2024, en las
R. Daniel Suarez-Jiménez, Esaú Ruiz-Sánchez, Luis Latournerie-Moreno, Aldo D. Chan-Arjona, Horacio S. Ballina-Gómez, Jhibran Ferral Piña   +5 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Especies de cicadellidae (hemiptera: auchenorrhyncha) asociadas a gramíneas

AIA Avances en Investigación Agropecuaria
Introducción. Las especies de la familia Cicadellidae se caracterizan por su impacto directo (consumo de savia) e indirecto (transmisión de enfermedades) en los cultivos agrícolas.
Ana Monserrat Guzmán-Hernández, Aldo Daniel Chan-Arjona   +1 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source