Results 91 to 100 of about 4,245,387 (333)

Situation analysis of parasitological and entomological indices of onchocerciasis transmission in three drainage basins of the rain forest of South West Cameroon after a decade of ivermectin treatment

Parasites & Vectors, 2015
Background Community-Directed Treatment with Ivermectin (CDTI) is the main strategy adopted by the African Programme for Onchocerciasis control (APOC). Recent reports from onchocerciasis endemic areas of savannah zones have demonstrated the feasibility ...
Samuel Wanji, Jonas A Kengne-Ouafo, Mathias E Esum, Patrick W N Chounna, Nicholas Tendongfor, Bridget F Adzemye, Joan E E Eyong, Isaac Jato, Fabrice R Datchoua-Poutcheu, Elvis Kah, Peter Enyong, David W Taylor   +11 more
doaj   +1 more source

Capsid Modifications for Targeting and Improving the Efficacy of AAV Vectors

Molecular Therapy: Methods & Clinical Development, 2019
In the past decade, recombinant vectors based on a non-pathogenic parvovirus, the adeno-associated virus (AAV), have taken center stage as a gene delivery vehicle for the potential gene therapy for a number of human diseases.
H. Büning, A. Srivastava
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Mosquito-borne arboviruses of African origin: review of key viruses and vectors

Parasites & Vectors, 2018
Key aspects of 36 mosquito-borne arboviruses indigenous to Africa are summarized, including lesser or poorly-known viruses which, like Zika, may have the potential to escape current sylvatic cycling to achieve greater geographical distribution and ...
L. Braack, A. P. Gouveia de Almeida, Anthony J. Cornel, R. Swanepoel, C. de Jager   +4 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Morphological and Molecular Techniques as an Integrative Approach to Identifying Sandfly (Diptera: Psychodidae) Vectors of Leishmaniasis in the Jazan and Asir Regions, Southwestern Saudi Arabia

International Journal of Zoology
Sandflies are the primary vectors of leishmaniasis, a parasitic disease of major public health concern in Saudi Arabia. While morphological identification remains the standard for species classification in the Jazan and Asir regions, distinguishing ...
Elsiddig Noureldin, Hatim Almutairi, Abdulaziz Almane, Hasabelrasol Elhaj, Alabbas Tami, Anwar M. Hashem, Khalid Shrwani, Eltayeb Awadelkarim, Yahya Hobani, Ali Alasmari, Ashwaq Alnazawi, Maimonah Alghanmi, Yasser Alraey, Abdullah Algaissi, Saeed Alqhtani, Ommer Dafalla   +15 more
doaj   +1 more source

Visualizing Bags of Vectors [PDF]

, 2013
The motivation of this work is two-fold - a) to compare between two different modes of visualizing data that exists in a bag of vectors format b) to propose a theoretical model that supports a new mode of visualizing data.
Balasubramanian, Sriramkumar, Nagireddy, Raghuram Reddy   +1 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source