Results 71 to 80 of about 2,628,537 (340)

Morphological and Molecular Techniques as an Integrative Approach to Identifying Sandfly (Diptera: Psychodidae) Vectors of Leishmaniasis in the Jazan and Asir Regions, Southwestern Saudi Arabia

International Journal of Zoology
Sandflies are the primary vectors of leishmaniasis, a parasitic disease of major public health concern in Saudi Arabia. While morphological identification remains the standard for species classification in the Jazan and Asir regions, distinguishing ...
Elsiddig Noureldin, Hatim Almutairi, Abdulaziz Almane, Hasabelrasol Elhaj, Alabbas Tami, Anwar M. Hashem, Khalid Shrwani, Eltayeb Awadelkarim, Yahya Hobani, Ali Alasmari, Ashwaq Alnazawi, Maimonah Alghanmi, Yasser Alraey, Abdullah Algaissi, Saeed Alqhtani, Ommer Dafalla   +15 more
doaj   +1 more source

Mosquito-borne arboviruses of African origin: review of key viruses and vectors

Parasites & Vectors, 2018
Key aspects of 36 mosquito-borne arboviruses indigenous to Africa are summarized, including lesser or poorly-known viruses which, like Zika, may have the potential to escape current sylvatic cycling to achieve greater geographical distribution and ...
L. Braack, A. P. Gouveia de Almeida, Anthony J. Cornel, R. Swanepoel, C. de Jager   +4 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Population genetic structure analysis of Anopheles kleini in the Republic of Korea based on the mitochondrial COI gene

Malaria Journal
Background Anopheles kleini is a competent vector mainly observed in the northern, malaria-risk areas of the Republic of Korea (ROK). In this study, the population genetic structure of An.
Haneul Jung, BoGyeong Han, Jung-Won Ju, Hee-Il Lee, Hyun-Il Shin   +4 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Advances in Non-Viral DNA Vectors for Gene Therapy

Genes, 2017
Uses of viral vectors have thus far eclipsed uses of non-viral vectors for gene therapy delivery in the clinic. Viral vectors, however, have certain issues involving genome integration, the inability to be delivered repeatedly, and possible host ...
Cinnamon L. Hardee, L. M. Arévalo-Soliz, Benjamin D. Hornstein, L. Zechiedrich   +3 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

An update of the tsetse fly (Diptera: Glossinidae) distribution and African animal trypanosomosis prevalence in north-eastern KwaZulu-Natal, South Africa

Onderstepoort Journal of Veterinary Research, 2016
An unpredicted outbreak of African animal trypanosomosis or nagana in 1990 in north-eastern KwaZulu-Natal necessitated an emergency control programme, utilising the extensive cattledipping system in the area, as well as a reassessment of the tsetse and ...
Chantel J. de Beer, Gert J. Venter, Karin Kappmeier Green, Johan Esterhuizen, Daniel G. de Klerk, Jerome Ntshangase, Marc J.B. Vreysen, Ronel Pienaar, Makhosazana Motloang, Lundi Ntantiso, Abdalla A. Latif   +10 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source