Results 81 to 90 of about 982,237 (384)

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Quantitative Trait Locus Mapping and Identification of Candidate Genes Controlling Bolting in Spinach (Spinacia oleracea L.)

Frontiers in Plant Science, 2022
Spinach is a typical light-sensitive plant. Long days can induce early bolting, thereby influencing the regional adaptation, quality, and vegetative yield of spinach.
Qing Meng, Zhiyuan Liu, Chunda Feng, Helong Zhang, Zhaosheng Xu, Xiaowu Wang, Jian Wu, Hongbing She, Wei Qian   +8 more
doaj   +1 more source

Antagonist Targeting the Species‐Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti‐H. pylori Infection

Advanced Science, EarlyView.
This study demonstrates that the atypical dehydrogenase/isomerase FabX in Type‐II fatty acid biosynthesis pathway is essential for H. pylori infection by retaining unsaturated fatty acid synthesis and producing superoxide (ROS). A small molecule FBX‐1991 that specifically targets FabX to inhibit H.
Lin Zhang, Xiaoxue Ruan, Xudong Hang, Ding Heng, Chang Cai, Liping Zeng, Guoxin Zhang, Lu Zhou, Hongkai Bi, Liang Zhang   +9 more
wiley   +1 more source

Parabolic dunes in north-eastern Brazil [PDF]

Geomorphology 102, 460-471 (2008), 2007
In this work we present measurements of vegetation cover over parabolic dunes with different degree of activation along the north-eastern Brazilian coast. We are able to extend the local values of the vegetation cover density to the whole dune by correlating measurements with the gray-scale levels of a high resolution satellite image of the dune field.
arxiv   +1 more source

Gambaran Pengetahuan Dan Perilaku Ibu Dalam Pemberian Sayur Pada Anak Usia Prasekolah Di Kelurahan Sukajaya Palembang [PDF]

, 2019
Background: Vegetables have several benefits such as energy source, vitamin source, supporting eye health, immunity, and building the body cells. The impact of eating fewer vegetables on preschoolers can have an impact such as malnutrition, obesity risk,
Sari, Mega
core  

Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects

Advanced Science, EarlyView.
Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian, Shujiang Sun, Xinran Qiu, Junrui Wang, Yuanyuan Gao, Jianmei Chen, Xiang Han, Zhengyang Bao, Xiaohan Guo, Yuqi Sun, Yuxin Lin, Mengru Hu, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Jiangjuan Shao   +16 more
wiley   +1 more source

Transcriptome profiling of Cucumis metuliferus infected by Meloidogyne incognita provides new insights into putative defense regulatory network in Cucurbitaceae

Scientific Reports, 2017
Root-knot nematodes (RKN) represent extensive challenges to Cucurbitaceae crops. However, Cucumis metuliferus (Cm) is known to be resistant to Meloidogyne incognita (Mi) infections.
Jian Ling, Zhenchuan Mao, Mingjuan Zhai, Feng Zeng, Yuhong Yang, Bingyan Xie   +5 more
doaj   +1 more source

Genome-wide analysis of microRNA targeting impacted by SNPs in cucumber genome

BMC Genomics, 2017
Background microRNAs (miRNAs) are endogenous small RNAs that play important regulatory functions in plant development. Genetic variations in miRNAs sequences or their target-binding sites (microRNA-target interaction sites) can alter miRNA targets in ...
Jian Ling, Zhongqin Luo, Feng Liu, Zhenchuan Mao, Yuhong Yang, Bingyan Xie   +5 more
doaj   +1 more source

Consumer motivation and willingness to pay for “safer” vegetables in Ghana [PDF]

, 2016
This document is the Accepted Manuscript version of the following article: Iddrisu Yahaya, and Fred A. Yamoah, (2015) "Consumer motivation and willingness to pay for “safer” vegetables in Ghana", British Food Journal, Vol. 117 Issue: 3, pp.1043-1065, the
Adam, Faizal, Yahaya, Iddrisu, Yamoah, Fred   +2 more
core   +1 more source

Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus

Advanced Science, EarlyView.
Baicalin alleviates E. coli‐induced intestinal inflammation through dual mechanisms: direct inhibition of the TLR4/IRF/STAT signaling pathway to modulate macrophage polarization and antigen presentation, thereby regulating Th17/Treg cell differentiation; and microbiota‐mediated indirect effects via increasing Lactobacillus amylovorus abundance and ...
Shunfen Zhang, Ruqing Zhong, Miao Zhou, Kai Li, Huiyuan Lv, Huixin Wang, Ye Xu, Dadan Liu, Qiugang Ma, Liang Chen, Hongfu Zhang   +10 more
wiley   +1 more source