Results 231 to 240 of about 383,810 (341)

Antibody-based therapeutics and therapeutic development for diabetic retinopathy: targeting VEGF, Ang/Tie, and inflammatory pathways. [PDF]

Front Endocrinol (Lausanne)
Zong Y, Qiu S, Zhang H, Wu J, Du J, Kamoi K, Cen Z.   +6 more
europepmc   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

A cytokine receptor-targeting chimera toolbox for expanding extracellular targeted protein degradation. [PDF]

Proc Natl Acad Sci U S A
Kumru K, Yao Z, Holmes BB, Zhao F, Zhang Y, Ferrara E, Peters-Clarke TM, Leung KK, Wells JA.   +8 more
europepmc   +1 more source

Vascular Endothelial Growth Factor (VEGF) and Its Role in the Progression and Development of Breast Tumor

Ammar Ihsan Awadh, Abbas M Ajeed, Faris K. Khadir, Haidar A. Abdulamir   +3 more
openalex   +2 more sources

Precise Regulation of Membrane Proteins: From Physical Technology to Biomolecular Strategy

Advanced Science, EarlyView.
This review summarizes the emerging strategies for the precise regulation of membrane proteins using physical stimuli and biomolecule‐based tools. These methods provide new insights into cell regulation and offer promising directions for future disease treatment.
Xiu Zhao, Qingqing Zhou, Mengli Li, Wen Zou, Zhenzhong Zhang, Jinjin Shi, Junjie Liu   +6 more
wiley   +1 more source

Synergistic therapy for diabetic retinopathy via dual blockade of VEGF-A and TNF-α with a bispecific nanobody. [PDF]

Front Pharmacol
Wu C, Shen Y, Xu C, Bi C, Yan C, Niu J, Zheng W, Ma X.   +7 more
europepmc   +1 more source

Avanços no Tratamento da Retinopatia Diabética: Uma Revisão Sistemática sobre Eficácia e Segurança das Terapias Anti-VEGF

Euller Condé Fernandes, Janaína Munuera Monteiro, Sónia Cabral, Natália Araújo, Matheus Wilson Santos Coelho, Fernando Malachias de Andrade Bergamo, Igor Heineck Ouriques, Charles Bonatti do Vale Silva, L. A. Souza, Rhuan Nantes Fontoura Teófilo, Carolina Dossena   +10 more
openalex   +2 more sources

VEGF: A potential biomarker in cardiovascular pathophysiology

, 2015
VEGF-A is involved in several diseases, including cardiovascular disease and several types of cancer. The existence of common signaling between the VEGF-A, cell adhesion molecules and inflammatory molecules may help to explain the wide range of functions of VEGF-A in different pathological situations.
openaire   +1 more source

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

EGF‐R is Expressed and AP‐1 and NF‐κ:B Are Activated in Stromal Myofibroblasts Surrounding Colon Adenocarcinomas Paralleling Expression of COX‐2 and VEGF [PDF]

, 2007
Panagiotis A. Konstantinopoulos, Gerasimos P. Vandoros, Michalis V. Karamouzis, Maria Gkermpesi, Georgia Sotiropoulou‐Bonikou, Athanasios G. Papavassiliou   +5 more
openalex   +1 more source