Results 271 to 280 of about 383,810 (341)

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Beyond VEGF and TGF-β: A Comprehensive Review of Growth Factor Pathways in the Pathophysiology of Uterine Leiomyomas. [PDF]

Biology (Basel)
Rozmurat N, Terzic S, Zhao P, Bapayeva G, Kongrtay K, Tanko MN, Terzic M.   +6 more
europepmc   +1 more source

Signal interaction between Norrin and VEGF promotes blood-retinal barrier restoration

, 2017
Monica Diaz Coranguez, Cheng‐mao Lin, Stefan Liebner, David A. Antonetti   +3 more
openalex   +1 more source

Targeting VEGF G-Quadruplex DNA with Chlorhexidine: A Biophysical and In Silico Approach for Cancer Therapy

Chinnadurai, Raj Kumar, Ghosal, Souvik, Bag, Sagar, Burman, Mangal Deep, Bhowmik, Sudipta   +4 more
openalex   +1 more source

A Kinetic Study of anti-VEGF-A Polyclonal Antibodies and anti-VEGF-A ssDNA Aptamers

, 2016
openaire   +2 more sources

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

IL-6 trans-signaling: an overlooked driver of retinal neovascularization? [PDF]

Angiogenesis
Jung M, Ness JN, Schwämmle ME, Rapp J, Boneva S, Groß O, Mitschke J, Schlunck G, Agostini H, Hannibal L, Bucher F.   +10 more
europepmc   +1 more source

Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans

Gavin, Timothy P., Stallings, Howard W., Zwetsloot, Kevin A., Westerkamp, Lenna M., Ryan, Nicholas A., Moore, Rebecca A., Pofahl, Walter E., Hickner, Robert C.   +7 more
openalex   +1 more source

Immunomodulatory Hydrogel Coating with SeNPs and Lithium Silicate Synergistically Promotes Osseointegration and Prevents Infection on Titanium Implants

Advanced Science, EarlyView.
This study introduces a multifunctional hydrogel coating (Lap‐CMCSMA/GelMA@SeNPs) that scavenges ROS, modulates immune responses, and shows strong antibacterial activity. It effectively restores the peri‐implant microenvironment. The coating exhibits excellent biocompatibility and promotes osteogenic differentiation.
Su Jiang, Baisheng Cai, Cong Ye, Kefan Wu, Kuan Liu, Pengcheng Xu, Fan Liu, Yake Liu   +7 more
wiley   +1 more source

If a patient experiences a single floater immediately after an intravitreal anti-VEGF injection, will it resolve over time? If yes, how long does it take?

Tripdatabase
openalex   +1 more source