Results 341 to 350 of about 717,961 (381)

Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span

Science, 2021
More VEGF, more life span and health span Advanced aging is celebrated but its ill effects of deterioration at the cell, tissue, and organ levels are not. Grunewald et al.
M. Grunewald, S. Kumar, H. Sharife, E. Volinsky, Alex Gileles-Hillel, T. Licht, A. Permyakova, L. Hinden, S. Azar, Y. Friedmann, P. Kupetz, R. Tzuberi, A. Anisimov, K. Alitalo, M. Horwitz, S. Leebhoff, O. Khoma, R. Hlushchuk, V. Djonov, R. Abramovitch, J. Tam, E. Keshet   +21 more
semanticscholar   +1 more source

Molecular mechanism of VEGF and its role in pathological angiogenesis

Journal of Cellular Biochemistry, 2022
Over the last seven decades, a significant scientific contribution took place in the delineation of the implications of vascular endothelial‐derived growth factor (VEGF) in the processes of angiogenesis.
A. Ahmad, M. Nawaz
semanticscholar   +1 more source

Novel VEGF family members: VEGF-B, VEGF-C and VEGF-D

The International Journal of Biochemistry & Cell Biology, 2001
Vascular endothelial growth factors (VEGFs) constitute a group of structurally and functionally related growth factors that modulate many important physiological functions of endothelial cells. Currently, five different mammalian VEGFs have been identified and they all show unique temporal and spatial expression patterns, receptor specificity and ...
X, Li, U, Eriksson
openaire   +2 more sources

VEGF antagonists

Expert Opinion on Biological Therapy, 2001
The majority of cancer have an absolute requirement for angiogenesis, the process by which new blood vessels are formed. The most potent angiogenic cytokine is vascular endothelial growth factor (VEGF) and there has been substantial research into the development of VEGF/VEGF receptor (VEGFR) antagonists.
Hasan, J, Jayson, G
openaire   +3 more sources

Current biology of VEGF-B and VEGF-C

Current Opinion in Biotechnology, 1999
Endothelial growth factors and their receptors may provide important therapeutic tools for the treatment of pathological conditions characterised by defective or aberrant angiogenesis. Vascular endothelial growth factor (VEGF) is pivotal for vasculogenesis and for angiogenesis in normal and pathological conditions.
B, Olofsson, M, Jeltsch, U, Eriksson, K, Alitalo   +3 more
openaire   +2 more sources

VEGF and VEGF receptors are differentially expressed in chondrocytes

Bone, 2007
During long bone development, cartilage replacement by bone is governed in part by angiogenesis. Although it has been demonstrated that vascular endothelial growth factor (VEGF-A) is crucial during endochondral ossification, little is known about the involvement of the other VEGF family members.
Bluteau, G., Julien, M., Magne, D., Mallein-Gerin, F., Weiss, P., Daculsi, G., Guicheux, J.   +6 more
openaire   +3 more sources

Unique signal transduction of the VEGF family members VEGF-A and VEGF-E

Biochemical Society Transactions, 2009
Both VEGF (vascular endothelial growth factor)-A and Orf-virus-encoded VEGF-E bind and activate VEGFR (VEGF receptor)-2; however, only VEGF-A binds VEGFR-1. To understand the biological differences between VEGF-A and VEGF-E in vivo, we established transgenic mouse models.
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VEGF and ALS

Neuroscience Research, 2008
In amyotrophic lateral sclerosis (ALS), an adult-onset progressive degeneration of motor neurons occurring as sporadic and familial disease, there is emerging evidence for and against the role of vascular endothelial growth factor (VEGF), an endothelial cell mitogen crucial for angiogenesis, in its etiopathogenesis.
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Molecular Biology of the VEGF and the VEGF Receptor Family

Seminars in Thrombosis and Hemostasis, 2000
Vascular endothelial growth factor (VEGF) is the founding member of a still growing family of endothelial cell growth factors. The diverse functions of VEGF and its homologues (PIGF, VEGF-B, VEGF-C, VEGF-D, and VEGF-E) can be explained by their differential binding to the three signaling VEGF receptors.
openaire   +2 more sources

[VEGF, anti-vEGF and diseases].

Bulletin de l'Academie nationale de medecine, 2008
Angiogenesis is a rapidly growing research field. Most of the important vascular growth factors have been identified in the space of a few years, as well as factors responsible for the diferentiation of arteries, veins and lymphatic vessels. The role of angiogenesis in tumor growth, exsudative retinopathies and some inflammatory diseases has been ...
openaire   +1 more source