Results 21 to 30 of about 2,650,230 (376)
Structure and function of VEGF receptors
IUBMB Life, 2009 AbstractVascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development and homeostasis. VEGFs are predominantly produced by endothelial, hematopoietic, and stromal cells in response to hypoxia and upon stimulation by growth factors such as transforming growth factor β (TGFβ), interleukins, or platelet‐derived growth factors
E. Stuttfeld, K. Ballmer-Hofer
semanticscholar +3 more sources
Aflibercept—a Decoy VEGF Receptor [PDF]
Current Oncology Reports, 2014 Aflibercept (known as ziv-aflibercept in the USA and sold under the trade name Zaltrap®) is a human recombinant fusion protein with antiangiogenic effects that functions as a decoy receptor to bind vascular endothelial growth factors A and B and placental growth factor.
Kristen K, Ciombor, Jordan, Berlin
openaire +2 more sources
Journal of Translational Medicine, 2022 Background An imbalance in the expression of vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) during pregnancy plays an important role in the pathogenesis of gestational diabetes mellitus (GDM) and eclampsia.
Alayi Bolatai, Yujing He, Na Wu
doaj +1 more source
Cellular Physiology and Biochemistry, 2017 Background: Neuropathic pain is a type of chronic pain that results from dysfunctions of the somatosensory nerve system. This study was aimed to investigate the effect of mTOR/VEGF signaling pathway on neuropathic pain and the regulation mechanisms of ...
Xiaojuan Xie +4 more
doaj +1 more source
H3 histamine receptor-mediated activation of protein kinase calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo [PDF]
, 2009 Histamine regulates functions via four receptors (HRH1, HRH2, HRH3, and HRH4). The D-myo-inositol 1,4,5-trisphosphate (IP(3))/Ca(2+)/protein kinase C (PKC)/mitogen-activated protein kinase pathway regulates cholangiocarcinoma growth.
A. Vetuschi +13 more
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VEGF receptor signaling in vertebrate development [PDF]
Organogenesis, 2008 The secreted glycoprotein vascular endothelial growth factor A (VEGF or VEGFA) affects many different cell types and modifies a wide spectrum of cellular behaviors in tissue culture models, including proliferation, migration, differentiation and survival.
Vieira, J., Ruhrberg, C., Schwarz, Q.
openaire +4 more sources
Positive and negative regulation of angiogenesis by soluble vascular endothelial growth factor receptor-1 [PDF]
, 2018 Vascular endothelial growth factor receptor (VEGFR)-1 exists in different forms, derived from alternative splicing of the same gene. In addition to the transmembrane form, endothelial cells produce a soluble VEGFR-1 (sVEGFR-1) isoform, whereas non ...
Carbo, Miriam +2 more
core +5 more sources
The Role of Rho GTPases in VEGF Signaling in Cancer Cells
Analytical Cellular Pathology, 2020 Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its intracellular signaling and downstream
Nada El Baba +5 more
doaj +1 more source
Veterinary Sciences, 2022 Cutaneous squamous cell carcinoma (CSCC) is a common malignant skin cancer with a significant impact on health, and it is important to determine the degree of reliance of CSCC on angiogenesis for growth and metastasis.
Erwin Kristobal Gudenschwager-Basso +4 more
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Angiotensin II and VEGF are Involved in Angiogenesis Induced by Short-Term Exercise Training [PDF]
, 2001 Results from our laboratory have suggested a pathway involving angiotensin II type 1 (AT1) receptors and vascular endothelial growth factor (VEGF) in angiogenesis induced by electrical stimulation.
Amaral, Sandra L. +2 more
core +2 more sources