Impact of ligand binding on VEGFR1, VEGFR2, and NRP1 localization in human endothelial cells. [PDF]
PLoS Computational BiologyThe vascular endothelial growth factor receptors (VEGFRs) bind to cognate ligands to facilitate signaling pathways critical for angiogenesis, the growth of new capillaries from existing vasculature. Intracellular trafficking regulates the availability of
Sarvenaz Sarabipour +6 more
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Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. [PDF]
Journal of Clinical Investigation, 2000 Y. Kasahara +7 more
semanticscholar +2 more sources
Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. [PDF]
Journal of Clinical Investigation, 1995 R. Tuder, B. E. Flook, N. F. Voelkel
semanticscholar +2 more sources
Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives [PDF]
Signal Transduction and Targeted TherapyVascular endothelial growth factor (VEGF) signaling is a critical regulator of vasculogenesis, angiogenesis, and lymphangiogenesis, processes that are vital for the development of vascular and lymphatic systems, tissue repair, and the maintenance of ...
Chunsik Lee +5 more
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Comparative in silico Survey of Retinoic Acids as Putative Biomolecules Against VEGF Receptors: A Glycomics-based Approach [PDF]
Journal of Cell and Molecular Research, 2021 In this study, putative interactions between all of the retinoic acid (RA) ligands (all-trans (At), 9-cis (9c), and 13-cis (13c)), and VEGF receptors (VEGFR-1, -2 and -3) were investigated.
Ali Fallah +3 more
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An Investigation of Vascular Endothelial Growth Factor (VEGFR-1 and VEGFR-2) in Burn Wound Healing [PDF]
Archives of Razi Institute, 2022 Burn damage is a complicated trauma that causes local and general tissue edema as a result of cell breakage and capillary leak syndrome. Angiogenesis plays a key part in the mechanisms that are initiated by tissue damage (e.g., burns) since it works ...
L Abdulazeem, A Tariq, Saade Jasim
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Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells [PDF]
Oncogene, 2000 S. Kanno +8 more
semanticscholar +2 more sources
Nephrotoxicity induced by vascular endothelial growth factor inhibitors [PDF]
Journal of Nephropharmacology, 2022 Vascular endothelial growth factor (VEGF) is a special mitogen for vascular endothelial cells, an essential endogenous angiogenic cytokine, and the principal controller of vascular growth that plays a fundamental role in therapeutic angiogenesis pathways.
Shirinsadat Badri +5 more
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Specific dynamics in vascular endothelial growth factors (VEGF) in blood of patients with vitamin D-resistant rickets during correction of multiplanar deformities of lower limbs [PDF]
Гений oртопедии, 2020 Background Vitamin D-resistant rickets is a systemic disease with impaired bone remodeling that interferes with orthopaedic treatment of musculoskeletal pathologies.
Nikita S. Gvozdev +5 more
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The Role of VEGF and VEGF Receptors in Carcinogenesis [PDF]
Journal of Carcinogenesis & Mutagenesis, 2012 The vascular endothelial growth factor (VEGF) family and its associated cognate receptors are critical components of angiogenesis, the process of new blood vessel formation. Under normal conditions, angiogenesis supports organism development and tissue homeostasis in a tightly controlled fashion.
Kendall S. Frazier, Kevin French
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