Results 221 to 230 of about 17,703,275 (296)

Design, synthesis, and anticancer evaluation of novel pyrazole-thiophene hybrid derivatives as multitarget inhibitors of wild EGFR, mutant (T790M) EGFR, and VEGFR-2. [PDF]

RSC Adv
Sallam MN, Al-Karmalawy AA, Abbass EM, Hawas SS, El-Naggar AM, Hassan AMA.   +5 more
europepmc   +1 more source

A new perspective on radiotherapy in the comprehensive treatment of cancer

Precision Radiation Oncology, Volume 10, Issue 2, Page 165-183, June 2026.
Radiotherapy remains a key component in the comprehensive management of cancer. Its effectiveness is significantly improved through strategic combinations with chemotherapy, targeted therapy, and immunotherapy, providing a range of therapeutic outcomes from cure to palliative care.
Yingze Ma, Hongxuan Yu, Shijie Shang, Shixin Shan, Dawei Chen   +4 more
wiley   +1 more source

Novel chalcone 2-thiopyrimidine conjugates as dual VEGFR-2/BRAF inhibitors: design, synthesis, <i>in vitro</i> cytotoxicity, and molecular docking study. [PDF]

RSC Med Chem
Abdelaziz RAI, Allam HA, El Kerdawy AM, Abo-Elfadl MT, Abbas SE, Ghannam IAY.   +5 more
europepmc   +1 more source

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi   +7 more
wiley   +1 more source

Discovery of thieno[2,3-<i>d</i>]pyrimidine-based dual Aurora B/VEGFR-2 inhibitors with potent anticancer activity: molecular docking, mechanistic studies, and <i>in vivo</i> validation in a breast cancer model. [PDF]

RSC Adv
El-Shafey HW, Hamdi A, Elnagar MR, Gebril SM, Haikal A, El-Azab AS, Brogi S, Al-Suwaidan IA, Abdel-Aziz AA.   +8 more
europepmc   +1 more source

Natural Monoterpene Stylosin Induced Anticancer Effects on Human Colon Carcinoma Cells

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Extraction of STL from Ferula ovina by TLC and structural confirmation by 1H NMR. Favorable pharmacokinetics. Reduced CRC cell viability in a time‐ and dose‐dependent manner. Induced apoptosis. Interacted with the active site of HGFR. ABSTRACT Colorectal carcinoma (CRC) ranks among the top five most common malignancies globally, characterized by a high
Sara Seyedshazileh, Amirabbas Abdollahi, Mehrdad Iranshahi, Fatemeh B. Rassouli   +3 more
wiley   +1 more source

Anti-breast cancer potential of thieno-pyrimidine derivatives as VEGFR-2 inhibitors. [PDF]

Future Med Chem
Alsfouk AA, Al Ward MMS, Al-Qadhi MA, El-Metwally SA, Yousef RG, Elkaeed EB, Husein DZ, Amin FG, Elkady H, Metwaly AM, Eissa IH.   +10 more
europepmc   +1 more source

Prospective Multicenter Observational Study of Anlotinib in Advanced Non‐Small Cell Lung Cancer: Real‐World Evidence From China

Thoracic Cancer, Volume 17, Issue 11, June 2026.
In this prospective real‐world study, anlotinib demonstrated meaningful efficacy and manageable safety in advanced NSCLC. ABSTRACT Background Anlotinib has shown remarkable efficacy in later‐line treatment of advanced non‐small cell lung cancer (NSCLC).
Jinlin Wang, Youhong Dong, Fengjun Cao, Ruizhi Ran, Yifa Yin, Yinping Li, Yang Fu, Yanhua Xu, Li Kuang, Guiming Chen, Guangqiao Qu, Jun Li, Zhiguo Luo, Qibin Song, Yuan Chen, Xinhua Xu, Tienan Yi, Qian Chu   +17 more
wiley   +1 more source

Synthesis of thiazoloquinolinone derivatives: molecular docking, MD simulation, and pharmacological evaluation as VEGFR-2 inhibitors. [PDF]

BMC Chem
Amiri Z, Bayat M, Gheidari D.
europepmc   +1 more source

The Aging Microenvironment Shapes Angiogenic Remodeling in IBD‐Associated Colorectal Carcinogenesis

Aging Cell, Volume 25, Issue 6, June 2026.
In IBD, chronic inflammation promotes cellular senescence across epithelial, stromal, endothelial, and immune compartments. The resulting SASP drives pathological angiogenesis, vascular dysfunction, hypoxia, and immune suppression, thereby facilitating progression from inflammation to dysplasia and colitis‐associated colorectal cancer.
Ruoshu Duan, Qingyu Chen, Yuan Xu, Ye Yan, Sujing Jiang   +4 more
wiley   +1 more source