Results 201 to 210 of about 17,703,275 (296)

miR‐941 in extracellular vesicles confers anlotinib resistance via Keap1/Nrf2 axis and represents a therapeutic target in non‐small cell lung cancer

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
EV‐derived miR‐941 as a key driver of anlotinib resistance via the Keap1/Nrf2 pathway represent a promising non‐invasive predictive biomarker and a potential therapeutic target for overcoming resistance in NSCLC. Abstract Background Anlotinib is a multitargeted tyrosine kinase inhibitor for the treatment of advanced non‐small cell lung cancer (NSCLC ...
Aimi Huang, Xiaoqi Li, Erpeng Wu, Menglan Hao, Weimin Wang, Jinjing Xia   +5 more
wiley   +1 more source

Antiproliferation, 3D-multicellular spheroid and VEGFR-2 inhibitory properties of spiroindolin-2-ones with phosphonate function. [PDF]

Sci Rep
Hassan SM, Farid A, Bekheit MS, Panda SS, Kariuki BM, Abdelnaser A, Nasr S, Fayad W, El-Manawaty MA, Soliman AAF, Girgis AS.   +10 more
europepmc   +1 more source

Design and synthesis of thiadiazoles as anticancer, apoptotic, and VEGFR-2 inhibitors. [PDF]

Future Med Chem
Elgammal WE, Elkady H, Dahab MA, Mahdy HA, Hagras M, Nofal A, Alsfouk BA, Elkaeed EB, Eissa IH, Metwaly AM.   +9 more
europepmc   +1 more source

Novel Sulfonamide Derivatives as Anticancer Agents, VEGFR‑2 Inhibitors, and Apoptosis Triggers: Design, Synthesis, and Computational Studies. [PDF]

ACS Omega
Al-Ziyadi SH, Halawa AH, Belal A, Albezrah NKA, Obaidullah AJ, Abdelshafi NS, Al-Shareef HF, Mehany ABM, Hassan SM, Elgammal WE.   +9 more
europepmc   +1 more source

PET/CT and PET/MRI in Cancer Diagnosis and Management: A Comparative Clinical Perspective

iMetaMed, Volume 2, Issue 2, June 2026.
This review compares PET/CT and PET/MRI in cancer imaging, highlighting their complementary roles for precise diagnosis and staging. It evaluates their technical strengths, clinical performance across various cancers, and future directions, including AI and novel tracers.
Zijian Ding, Ran Xue, Qianxi Jin, Wangzheqi Zhang, Yali Wu, Baixuan Xu   +5 more
wiley   +1 more source

Pyrazolo[3,4-<i>d</i>]pyrimidine derivatives as VEGFR-2 and EGFR^T790M dual inhibitors: design, docking, ADMET, synthesis and anticancer evaluations. [PDF]

RSC Adv
Aziz NAAM, George RF, Nasr T, El-Adl K, Elmasry GF.   +4 more
europepmc   +1 more source

Exosomal Oleic Acid Promotes Lymphangiogenesis and Nodal Metastasis in Cervical Cancer via the AKT/mTOR Pathway

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Cervical cancer exosomes deliver SCD‐dependent oleic acid to LECs, activating AKT/mTOR to drive VEGF‐independent lymphangiogenesis and nodal metastasis, identifying exosomal OA as a therapeutic target. ABSTRACT Cervical cancer (CC) exhibits a pronounced tropism for regional lymphatic dissemination, a process driven by tumor‐associated lymphangiogenesis.
Jinqiu Li, Xiaojing Huang, Guzhalinuer Abulizi, Ayshamgul Hasim   +3 more
wiley   +1 more source

Development of the 5‑Nitrosalicaldehyde Arylhydrazones as Anticancer (MCF‑7 and HCT116) Agents Targeting Inhibition of VEGFR‑2 and Cytokines (IL‑6 and TNF-α). [PDF]

ACS Omega
Nkoana JK, More GK, Elhenawy AA, Mphahlele MJ.   +3 more
europepmc   +1 more source

Regulation of Immune Checkpoints: From Molecular Mechanisms to Clinical Therapies

MedComm, Volume 7, Issue 6, June 2026.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment by unleashing antitumor immunity. This review comprehensively examines the molecular mechanisms underlying key immune checkpoints—including PD‐1/PD‐L1, CTLA‐4, and TIM‐3—and their clinical applications.
Qintao Ge, Liu Yu, Jiahe Lu, Aihetaimujiang Anwaier, Xiyue Xiao, Yonghao Chen, Dingwei Ye, Hailiang Zhang, Wenhao Xu, Wenbin Dai   +9 more
wiley   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source