Results 141 to 150 of about 13,168 (265)

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Integration of Active Chassis Control Systems for Improved Vehicle Handling Performance

This thesis investigates the principle of integration of vehicle dynamics control systems by proposing a novel control architecture to integrate the brake-based electronic stability control (ESC), active front steering (AFS), normal suspension force ...
Rengaraj, Chandrasekaran
core  

Nonlinear Automotive Vehicle Suspension System Integrated With Enhanced PID Controller

, 2023
This work presents a comprehensive study on a Nonlinear Quarterly Car Passive Suspension System (PSS), designed to address the dynamic challenges encountered in modern vehicles.
Gubio, Sherif
core  

Study on Operation Stability of New Four Modules Middle-low Speed Maglev Vehicles on a Straight Track

机车电传动, 2020
The operation stability of new four modules middle-low speed air spring center-position maglev vehicle was simulated by using the SIMPACK. The simulation results showed that when the speed of maglev vehicle exceeded a certain critical speed on a straight
Yuanzhuo HONG, Huajun LUO, Laisheng TONG, Feng GAO, Wenyue ZHANG, Qingsheng GUO   +5 more
doaj  

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Modelling and Simulation of an Experimental Vehicle with Magnetorheological Dampers

, 2004
Semi-active dampers with magnetorheological fluids are a well suited alternative for the classical hydraulic dampers with controllable orifice in many application areas including automotive.
Tapavicza, M. von, Bose, L., Altmann, F., Vaculin, O.   +3 more
core  

Mathematical modeling and optimization of the active suspension system of a 6x6 electric vehicle

Alexandria Engineering Journal
Vehicle suspension systems have a significant role in the capacity of transmit forces coming from the road and in vehicle performance. Loads between the road and the vehicle body significantly affect driver health, comfort, and vehicle drive features ...
Berk Aydoğan, Ahmet Yildiz
doaj   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Ride diagram : A tool for analysis of vehicle suspension settings

, 2006
This paper proposes a new evaluation method for ride comfort, the ride diagram. The ride diagram is plotted from vehicle accelerations resulting from increased levels of excitation.
Strandemar, Katrin,, Thorvald, Boris,
core   +1 more source