Results 31 to 40 of about 1,216,022 (275)

Bias‐compensated affine‐projection‐like algorithms with noisy input

Electronics Letters, 2016
A new class of bias‐compensated affine‐projection‐like (APL) algorithms is proposed, in which a bias‐compensation vector is derived to eliminate the bias caused by the noisy input.
Haiquan Zhao, Zongsheng Zheng
doaj   +1 more source

Research on Height Adjustment Characteristics of Heavy Vehicle Active Air Suspension Based on Fuzzy Control

World Electric Vehicle Journal, 2023
The suspension system’s performance has a direct impact on the ride comfort, handling stability, and driving safety of heavy vehicles. The active air suspension of heavy vehicles can adjust the stiffness, damping parameters, and body height in real-time ...
Xin Bai, Liqun Lu, Can Zhang, Wenpeng Geng   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Analysis and optimization of the vehicle handling stability with considering suspension kinematics and compliance characteristics

Advances in Mechanical Engineering, 2021
The dynamic model of the front double wishbone suspension and the rear multi-link suspension of the vehicle are established. On the basis of detailed analysis of suspension kinematics, calculation method of wheel alignment angle and force calculation of ...
Jin Gao, Fuquan Wu
doaj   +1 more source

Active Suspension Control Strategy of Multi-Axle Emergency Rescue Vehicle Based on Inertial Measurement Unit

Sensors, 2021
Active suspension control strategies are a top priority in active suspension system. The current research on active suspension control strategies is mostly focused on two-axle vehicles, and there is less research investigating multi-axle vehicles ...
Qinghe Guo, Dingxuan Zhao, Xiaolong Zhao, Zhenxing Li, Xiaobo Shi   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

VEHICLE SUSPENSION SYSTEM MODELLING AND SIMULATION IN THE SOLIDWORKS SOFTWARE ENVIRONMENT WITH MOTION ANALYSIS APPLICATIONS [PDF]

Scientific Journal of Silesian University of Technology. Series Transport, 2017
An N1 vehicle model is created, which allows for changing suspension parameters and conditions of experimental performance. A methodology of computer testing performance for vehicle ride comfort and stability service properties’ characterization in a ...
Serhiy MELNYCHUK, Ivan VITIUK, Ihor BOVSUNIVSKYI, Dmytro BEHERSKYI, Yuriy KUBRAK   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The Influence of Vehicle Tyres Pressure on the Suspension System Response by Applying the Time-Frequency Approach [PDF]

, 2013
Maintaining correct inflation pressure in tires helps to keep vehicle handling, passenger comfort and braking at its best, as well as improving fuel efficiency and tire life. Therefore it is very important that the tires are correctly inflated.
Gu, Fengshou, Ball, Andrew, Li, G., Aliwan, M., Tesfa, Belachew, Hamed, M.   +5 more
core   +3 more sources