Results 71 to 80 of about 80,410 (267)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Advances in Sustainable and Wearable Textile Based Soft Robotics

Advanced Functional Materials, EarlyView.
This Review examines advances in wearable textile‐based soft robotics, focusing on sustainable materials, integrated sensing, and scalable actuation. It discusses manufacturing and system integration across healthcare, assistive robotics, prosthetics, and human–machine interfaces, and highlights key challenges in circular design, including life‐cycle ...
Zahir Abbas, Marzia Dulal, Sophia K. Novoselov, Victoria K. Novoselov, Kostya S. Novoselov, Shaila Afroj, Nazmul Karim   +6 more
wiley   +1 more source

Optimization of Steering Torque for Suspended Monorail Vehicle

机车电传动, 2020
From the perspective of vehicle design and optimization of system dynamics parameters, a method for optimizing the guidance performance of suspended monorail vehicles was explored. Firstly, the structure of the suspended monorail vehicle was analyzed. On
Fei TANG, Yao LI, Fucheng ZHU, Long RAN
doaj  

Hierarchical MXene‐Derived NTP/C Nanohybrids for Cryogenic Sodium‐Ion Batteries

Advanced Functional Materials, EarlyView.
A hierarchical MXene‐derived NaTi2(PO4)3/C nanohybrid enables efficient sodium‐ion storage down to −40°C by integrating fast ion–electron transport pathways with an ether‐based electrolyte. The system promotes dominant pseudocapacitive behavior and forms a robust inorganic‐rich SEI, collectively mitigating kinetic and interfacial limitations, thereby ...
M. Sai Bhargava Reddy, Mohammad Zaid, Sayan Das, Sooryadas Sudhakaran, Shampa Aich, Vilas G. Pol   +5 more
wiley   +1 more source

Computational Modelling of the Rail Vehicle Multibody System Including Flexible Bodies

Communications, 2015
Tools for computer simulations are widely used in the field of a rail vehicle design. These means of virtual reality allow to perform static analyses of rail vehicle parts and dynamic analyses of a rail vehicle multibody system.
Jan Dizo, Miroslav Blatnicky, Blanka Skocilasova   +2 more
doaj   +1 more source

Nano‐Scale Characterization of Impurities Segregation in Solid Oxide Electrolysis Cells

Advanced Functional Materials, EarlyView.
Cathodic polarization induces impurity segregation in Ni, forming an amorphous Na─Al─Si─O amorphous phase at grain boundaries. Under ultralow oxygen partial pressure, multiple elements dissolve, migrate, and reoxidize within the metal. A patterned model system provides direct nanoscale evidence, clarifying the mechanism of polarization‐driven impurity ...
Zhongtao Ma, Qingjie Wang, Bowen Li, Vasileios Bilalis, Søren Bredmose Simonsen, Ming Chen   +5 more
wiley   +1 more source

DESIGN, SIMULATION AND CONTROL OF A NOVEL HYDRAULIC BRAKING SYSTEM [PDF]

Journal of the Egyptian Society of Tribology
A novel automatic braking system is designed in this research to decrease vehicles accidents caused by obstacles. A safer automatic braking system that can handle less driver attention to the driving is developed. The proposed system is operated by means
Sabry Allam, Hamdy aboeldaheb, Sabreen Abdelwahab   +2 more
doaj   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Electric Traction Emulator System

IEEE Access
This paper addresses the need for advanced research facilities to investigate electric traction systems, particularly control strategies, in the context of the increasing adoption of electric vehicles (EVs).
F. Perez Carmona, Jaime J. Rodriguez Rivas, R. Ortega Gonzalez, O. Carranza Castillo, D. Memije Garduno, E. Peralta Sanchez   +5 more
doaj   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source