Results 51 to 60 of about 376,937 (218)

Numerical study of wake and potential interactions in a two-stage centrifugal refrigeration compressor

Engineering Applications of Computational Fluid Mechanics, 2021
Both potential and wake interactions are usually the primary mechanisms related to the unsteadiness in turbomachines. However, it is usually difficult to distinguish their effects on flow evolution.
Chen Xu, Chuang Fan, Zhiping Zhang, Yijun Mao   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

CLASSICAL MOLECULAR DYNAMICS (MD) SIMULATION OF SALT AND SOLVENT SOLVATION EVENTS IN LITHIUM ION BATTERIES TO DETERMINE ENERGY FLUCTUATIONS

Jurnal Neutrino: Jurnal Fisika dan Aplikasinya
This study looks at how salt and solvent mix, as shown by the final positions of particles in a simulation. The simulation uses Lennard-Jones parameters and runs in a closed system with fixed energy. The goal is to see if the particles follow the Maxwell
Hubertus Ngaderman, Ego Srivajawaty Sinaga, Benny Abraham Bungasalu   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

IDENTIFICATION OF THE INTERACTION OF LITHIUM HEXAFLUOROPHOSPHATE SALT AND ETHYLENE CARBONATE (EC) SOLVENT IN LITHIUM ION BATTERY REDOX EVENTS USING CLASSICAL MOLECULAR DYNAMICS (MD) SIMULATION

Jurnal Neutrino: Jurnal Fisika dan Aplikasinya
The aim of the research is to find the maximum velocity possessed by the molecules (Maxwell velocity distribution) of the solvation event of lithium hexafluorophosphate salt  interacting with ethylene carbonate (EC) solvent.
Hubertus Ngaderman, Ego Srivajawaty Sinaga   +1 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Modeling the Terminal Velocity of Rising Electrocharged Microbubbles

Surfaces
The generation of electrocharged microbubbles is very important for several separation processes (e.g., water treatment, paper industry, and mineral processing). However, their rising terminal velocities are not fully understood.
Roberto Pérez-Garibay, Arturo Bueno-Tokunaga, Francisco Andrés Acosta-González, Ramón Arellano-Piña   +3 more
doaj   +1 more source