Results 61 to 70 of about 376,937 (218)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Geofluids and up-to-date display of activization of the Ingul megablock of the Ukrainian Shield
Геофизический журнал, 2014 High degree of geological-geophysical studies of crustal processes combined with analysis of 3D P-velocity model of the mantle under the Ukrainian Shield and its southern surrounding up to the depth of 2500 km allowed to correlate manifestations of ...
V. I. Starostenko +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Atrial Rate And Rhythm Abnormalities In A Patient With Hyperkalemia
Indian Pacing and Electrophysiology Journal, 2009 A 67 year old man presented with a serum potassium of 7.7 mEq/L and slow atrial flutter with variable A-V block and peaked T waves. Initial treatment for hyperkalemia was followed by an increase in the atrial flutter rate to 300 beats per minute.
Jonathan Rosman +4 more
doaj
Discussion about the characteristics of flow in atmospheric airflow field using the complex function
Atmospheric and Oceanic Science Letters, 2018 Different levels of fluctuation occur when airflow passes over different terrain. It is important for weather and climate change, as well as aviation and glider safety, to study the motion of airflow. Based on conformal mapping and the complex potential,
Yu WANG, Si-Xun HUANG
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A Path-Planning Method to Significantly Reduce Local Oscillation of Manipulators Based on Velocity Potential Field. [PDF]
Sensors (Basel), 2023 Wang X, Wu Q, Wang T, Cui Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
GeoHazardsThe 17 November 2023 MW 6.8 earthquake located offshore of Southern Mindanao, Philippines, triggered soil liquefaction along the lowlands of the Sarangani Peninsula. Detailed mapping, geomorphological interpretations, geophysical surveys, comparison with
Daniel Jose L. Buhay +8 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source