Results 71 to 80 of about 1,534,656 (293)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

IDENTIFICATION OF THE INTERACTION OF LITHIUM HEXAFLUOROPHOSPHATE SALT AND ETHYLENE CARBONATE (EC) SOLVENT IN LITHIUM ION BATTERY REDOX EVENTS USING CLASSICAL MOLECULAR DYNAMICS (MD) SIMULATION

open access: yesJurnal Neutrino: Jurnal Fisika dan Aplikasinya
The aim of the research is to find the maximum velocity possessed by the molecules (Maxwell velocity distribution) of the solvation event of lithium hexafluorophosphate salt  interacting with ethylene carbonate (EC) solvent.
Hubertus Ngaderman   +1 more
doaj   +1 more source

Anomalous Bloch oscillations in one dimensional parity-breaking periodic potentials

open access: yes, 2010
We investigate the dynamics of a wave packet in a parity-breaking one-dimensional periodic potential slowly varied in time and perturbed by a linear potential. Parity is broken by considering an asymmetric double well per unit cell.
Modugno, Michele, Pettini, Giulio
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Potential Vorticity and the Quasigeostrophic and Semigeostrophic MesoscaleVertical Velocity

open access: yesJournal of Physical Oceanography, 2004
Support for this research has come from the Spanish Ministerio de Ciencia y Tecnología Grant REN2002-01343 and the program Ramón y Cajal 2001, as well as the UK National Environmental Research Council (Grant GR3/11899)
Viúdez, Álvaro, Dritschel, David G.
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Modeling the Terminal Velocity of Rising Electrocharged Microbubbles

open access: yesSurfaces
The generation of electrocharged microbubbles is very important for several separation processes (e.g., water treatment, paper industry, and mineral processing). However, their rising terminal velocities are not fully understood.
Roberto Pérez-Garibay   +3 more
doaj   +1 more source

The Prevalence of Gas Outflows in Type 2 AGNs. II. 3D Biconical Outflow Models

open access: yes, 2016
We present 3D models of biconical outflows combined with a thin dust plane for investigating the physical properties of the ionized gas outflows and their effect on the observed gas kinematics in type 2 active galactic nuclei (AGNs). Using a set of input
Bae, Hyun-Jin, Woo, Jong-Hak
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Geofluids and up-to-date display of activization of the Ingul megablock of the Ukrainian Shield

open access: yesГеофизический журнал, 2014
High degree of geological-geophysical studies of crustal processes combined with analysis of 3D P-velocity model of the mantle under the Ukrainian Shield and its southern surrounding up to the depth of 2500 km allowed to correlate manifestations of ...
V. I. Starostenko   +3 more
doaj   +1 more source

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