Results 51 to 60 of about 157,231 (265)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Results of Jet Fan Tests using Experimental and Numerical Techniques
Safety & Fire Technology, 2020 Aim: The aim of the experiments was to check if different jet fans with similar parameters had a similar air flow profile. The study was also aimed at testing whether normal and reverse flow direction have the same profile.
Izabela Tekielak-Skałka +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Halo profile evolution and velocity bias [PDF]
Physical Review D, 2015 20 pages, 15 ...
openaire +2 more sources
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
MODELLING OF TURBULENT WAKE FOR TWO WIND TURBINES
Научный вестник МГТУ ГА, 2018 The construction of several large wind farms (The Ulyanovsk region, the Republic of Adygea, the Kaliningrad region, the North of the Russian Federation) is planned on the territory of the Russian Federation in 2018–2020.
A. S. Kryuchkova, S. V. Strijhak
doaj +1 more source
Numerical Simulation Results of Hydraulic Jump in Different Conditions of Roughness, Adverse Slope, and Positive Step [PDF]
علوم آب و خاک, 2023 Hydraulic jump is used for dissipation of kinetic energy downstream of hydraulic structures such as spillways, chutes, and gates. In the present study, the experimental measurements and numerical simulation of the free hydraulic jump by applying Flow-3D ...
N. Pourabdollah +2 more
doaj
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source