Results 61 to 70 of about 185,421 (315)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Measurement of the Velocity Profile in the Spirally Reinforced Pipe [PDF]

, 2017
In present paper, by installing the wind tunnel consisted of the spirally-reinforced-groove pipe with the diameter of 325mm, the velocity at different radial positions is measured in the text section where the flow is fully developed into the turbulent ...
张军, 钟兴福, 林黎明, 吴应湘
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MODELLING OF TURBULENT WAKE FOR TWO WIND TURBINES

Научный вестник МГТУ ГА, 2018
The construction of several large wind farms (The Ulyanovsk region, the Republic of Adygea, the Kaliningrad region, the North of the Russian Federation) is planned on the territory of the Russian Federation in 2018–2020.
A. S. Kryuchkova, S. V. Strijhak
doaj   +1 more source

Numerical Simulation Results of Hydraulic Jump in Different Conditions of Roughness, Adverse Slope, and Positive Step [PDF]

علوم آب و خاک, 2023
Hydraulic jump is used for dissipation of kinetic energy downstream of hydraulic structures such as spillways, chutes, and gates. In the present study, the experimental measurements and numerical simulation of the free hydraulic jump by applying Flow-3D ...
N. Pourabdollah, M. Heidarpour, Jahangir Abedi-Koupai   +2 more
doaj  

Algebraic Type Approximation to the Blasius Velocity Profile [PDF]

Journal of Applied Mathematics, 2014
For the Blasius velocity profile we propose a simple algebraic type approximate function which is uniformly accurate over the whole region. Moreover, for further improvement a correction method based on a weight function is introduced. The availability of the proposed method is shown by the result of numerical experiments.
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Improved structure of vertical flow velocity distribution in natural rivers based on mean vertical profile velocity and relative water depth

, 2017
Logarithmic, power, and parabolic distribution laws were proven to be efficient for the prediction of vertical velocity distribution. Traditionally, the distribution formulas involve the friction velocity (u*) and the depth (y) of the measurement point ...
Song, Song, S. Song, B. Schmalz, Fohrer, Nicola, N. Fohrer, Schmalz, Britta   +5 more
core   +1 more source