Results 61 to 70 of about 849,570 (300)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Determination of flow characteristics over sharp-crested triangular plan form weirs using numerical simulation

Water Science, 2023
Triangular plan form weirs are one type of long-crested weirs. Therefore, they can pass more discharge capacity than weirs at the given channel width. This study aims to investigate the effects of different number of teeth (3, 4, and 5 teeth), angle of ...
Rasoul Daneshfaraz, Reza Norouzi, John Patrick Abraham, Parisa Ebadzadeh, Behnaz Akhondi, Maryam Abar   +5 more
doaj   +1 more source

Concentration profiles for fine and coarse sediments suspended by waves over ripples: An analytical study with the 1-DV gradient diffusion model [PDF]

, 2010
Field and laboratory measurements of suspended sediments over wave ripples show, for time-averaged concentration profiles in semi-log plots, a contrast between upward convex profiles for fine sand and upward concave profiles for coarse sand.
Absi, Baldock, Blondeaux, Cheng, Conley, Di Felice, Dohmen-Janssen, du Toit, Fredsoe, Graf, Hsu, Lee, Nakato, Nielsen, Nielsen, Rafik Absi, Richardson, Thorne, Thorne, van der Werf   +19 more
core   +5 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

SLURRY FLOW MODELLING BY CFD [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2010
An attempt has been made in the present study to develop a generalized slurry flow model using CFD and utilize the model to predict concentration profile.
K.C. Ghanta, Sandip Kumar Lahiri
doaj  

Numerical and analytical flow models in ecological channels with interaction of vegetation and freshwater

Frontiers in Environmental Science, 2023
Aquatic vegetation interferes with river hydrodynamics, thus affecting the mass transport and energy transfer in an ecosystem. The flow over submerged vegetation is characterized by a complex velocity profile and multiple turbulence structures, which ...
Hanqing Zhao, Hanqing Zhao, Weijie Wang, Fengcong Jia, Huilin Wang, Zhiwu Liu, Yuxuan Xu, Yuxuan Xu   +7 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Velocity profile of granular flows inside silos and hoppers [PDF]

, 2005
We measure the flow of granular materials inside a quasi-two dimensional silo as it drains and compare the data with some existing models. The particles inside the silo are imaged and tracked with unprecedented resolution in both space and time to obtain
Arshad Kudrolli, Bazant M Z, Bazant M Z Choi J Rycroft C H Rosales R R Kudrolli A, Brown R C, Crank J, Duran J, Hsiau S S, Hsiau S S, Jaehyuk Choi, Jenkins J T, Kadak A C Bazant M Z, Litwiniszyn J, Litwiniszyn J, Litwiniszyn J, Martin Z Bazant, MiDi G D R, Natarajan V V R, Nedderman R M, Pitman E B, Prakash J R, Rycroft C H Bazant M Z Landry J Grest G S, Savage S B, Talbot D   +22 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

MODELLING OF TURBULENT WAKE FOR TWO WIND TURBINES

Научный вестник МГТУ ГА, 2018
The construction of several large wind farms (The Ulyanovsk region, the Republic of Adygea, the Kaliningrad region, the North of the Russian Federation) is planned on the territory of the Russian Federation in 2018–2020.
A. S. Kryuchkova, S. V. Strijhak
doaj   +1 more source