Results 71 to 80 of about 14,053 (243)

Western Diet Combined With Chemical Induction: A Strategy for Rapid Development of MASLD Pathology in Mice

iNew Medicine, EarlyView.
ABSTRACT The molecular mechanisms underlying the development of metabolic‐dysfunction‐associated steatotic liver disease (MASLD) are essential for developing appropriate treatments. The purpose of this study was to establish an MASLD model in mice with rapid and consistent progression.
Ting‐Ting Chen, Nan Li, Shuo Wang, Miao Sun, Rui Yang, Shi‐Hao Zhang, Xiao‐Lei Li, Chen Dong, Ke‐Yuan Chen, Wu‐Yi Sun, Na Zhou   +10 more
wiley   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

Integrative multi-omics analysis reveals the contribution of neoVTX genes to venom diversity of Synanceia verrucosa

BMC Genomics
Background Animal venom systems are considered as valuable model for investigating the molecular mechanisms underlying phenotypic evolution. Stonefish are the most venomous and dangerous fish because of severe human envenomation and occasionally ...
Zhiwei Zhang, Qian Li, Hao Li, Shichao Wei, Wen Yu, Zhaojie Peng, Fuwen Wei, Wenliang Zhou   +7 more
doaj   +1 more source

Extraction of Venom and Venom Gland Microdissections from Spiders for Proteomic and Transcriptomic Analyses [PDF]

Journal of Visualized Experiments, 2014
Venoms are chemically complex secretions typically comprising numerous proteins and peptides with varied physiological activities. Functional characterization of venom proteins has important biomedical applications, including the identification of drug leads or probes for cellular receptors. Spiders are the most species rich clade of venomous organisms,
openaire   +2 more sources

Assessment of Gold‐Mediated Male Reproductive Dysfunction in Male WISTAR Rats Through Sperm Analysis and Testosterone Measurement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Gold has been used for centuries in both ornamental and medicinal contexts. More recently, gold compounds, containing ions or nanoparticles, have attracted attention for their anti‐inflammatory, anticancer, and diagnostic applications. Therefore, concerns about systemic toxicity and biodistribution have prompted investigations into the ...
Samira Maghraoui, Adrian Florea, Leila Tekaya   +2 more
wiley   +1 more source

The effects of royal jelly on human health: A narrative review of clinical studies

JSFA reports, EarlyView.
Abstract Royal jelly (RJ) is a natural bioactive substance with documented effects on human health. This narrative review synthesizes evidence from clinical and clinically relevant experimental studies evaluating the therapeutic potential of RJ.
Georgios Goras, Andreas Thrasyvoulou, Evanthia Tsilimpokou   +2 more
wiley   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Profiling the resting venom gland of the scorpion Tityus stigmurus through a transcriptomic survey

BMC Genomics, 2012
Background The scorpion Tityus stigmurus is widely distributed in Northeastern Brazil and known to cause severe human envenoming, inducing pain, hyposthesia, edema, erythema, paresthesia, headaches and vomiting.
Almeida Diego D, Scortecci Katia C, Kobashi Leonardo S, Agnez-Lima Lucymara F, Medeiros Silvia R B, Silva-Junior Arnóbio A, Junqueira-de-Azevedo Inácio, Fernandes-Pedrosa Matheus   +7 more
doaj   +1 more source

(Dis)information Systems: a Systemic View of Disinformation

Systems Research and Behavioral Science, EarlyView.
ABSTRACT Disinformation is an ancient social phenomenon that has found a favourable environment for dissemination in internet‐based social networks. While the scientific community seeks to address the problem by creating specific tools to detect and classify the various types of false information, we argue that systems thinking is necessary to ...
Herbert Laroca, Vitor Rocio, Antonio Cunha   +2 more
wiley   +1 more source

Sargassum Lung Syndrome: Air Flow Obstruction and Bronchial Inflammation Are Observed After Prolonged Exposure to Sargassum Gas Emissions in the Eastern Caribbean

Environmental Toxicology, EarlyView.
ABSTRACT Sargassum inundation of Caribbean and American shorelines is a growing environmental hazard. Hydrogen sulfide (H2S) and ammonia (NH3) produced by decomposing Sargassum could be involved in airway obstruction and bronchial inflammation. The study was undertaken to evaluate the effects of exposure to H2S and NH3 gases emitted during Sargassum ...
Rishika Banydeen, Jonathan Florentin, Maxime Boutourlinsky, Remi Nguyen, Fatima Radouani, Moustapha Agossou, Gary Lutin, Thierry Lebrun, Remi Neviere, Dabor Resiere   +9 more
wiley   +1 more source