Results 111 to 120 of about 2,427 (259)

A Case for Anti‐IgE Vaccination

Allergy, EarlyView.
ABSTRACT Immunoglobulin E (IgE) plays a central role in allergic diseases by binding to the high‐affinity receptor FcεRI on mast cells and basophils, where allergen‐induced crosslinking triggers potent inflammatory responses. Various mechanisms by which IgE responses are generated and functionally regulated remain elusive despite many years of research.
Paul Engeroff, Zahra Gharailoo, Monique Vogel, Martin F. Bachmann   +3 more
wiley   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, EarlyView.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

Pioneering Comparative Proteomic and Enzymatic Profiling of Amazonian Scorpion Venoms Enables the Isolation of Their First α-Ktx, Metalloprotease, and Phospholipase A₂

Toxins
Scorpionism is a growing public health concern in Brazil, with the Amazon region presenting the highest mortality rates but remaining understudied, especially regarding local scorpion venoms composition.
Karla C. F. Bordon, Gabrielle C. Santos, Jonas G. Martins, Gisele A. Wiezel, Fernanda G. Amorim, Thomas Crasset, Damien Redureau, Loïc Quinton, Rudi E. L. Procópio, Eliane C. Arantes   +9 more
doaj   +1 more source

Markedly Increased Diamine Oxidase During Acute Anaphylaxis Is Associated With an Underlying Clonal Mast Cell Disorder

Clinical &Experimental Allergy, EarlyView.
We provide the first evidence that pronounced release of DAO during anaphylaxis is restricted to patients with clonal mast cell disorder. This finding offers possible functional support for the reported association between KIT p.D816V and anaphylaxis severity.
Matija Rijavec, Žan Kogovšek, Jezerka Inkret, Peter Kopač, Mitja Košnik, Peter Korošec   +5 more
wiley   +1 more source

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, EarlyView.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source

Variability in venom composition of European viper subspecies limits the cross-effectiveness of antivenoms [PDF]

, 2018
Duregotti, Elisa, Giampreti, Andrea, Locatelli, Carlo Alessandro, Lonati, Davide, Pirazzini, Marco, Rossetto, Ornella, Zanetti, Giulia   +6 more
core   +1 more source

Some observations on the beaked sea snake Enhydrina schistosa (Daudin, 1803) in the mudbank area, off Alapuzha, Kerala, southwest coast of India [PDF]

, 2015
Hook-nosed sea snake or beaked snake, Enhydrina schistosa were caught during experimental fishing operations in the mudbank region along central Kerala Coast at depths ranging from 6 to 12 m.
Abhilash, K S, Aswathy, K S, Jeyabaskaran, R, Khambadkar, L R, Kripa, V, Mohammed, Abbas A, Mohan, Gishnu, Prema, D, Vishnu, P G   +8 more
core  

A Pilot Randomised Controlled Dose‐Ranging Trial of Ant Venom Immunotherapy With and Without Delta‐Inulin Adjuvant

Clinical &Experimental Allergy, EarlyView.
Low dose (25mcg) jack jumper ant venom immunotherapy with or without Advax adjuvant, had similar efficacy to the current standard of care. Reduction in basophil activation test reactivity in response to treatment correlated with sting challenge outcome.
Thanh‐Thao Adriana Le, Troy Wanandy, Griffith B. Perkins, Susan Lester, Wun Yee Lau, Malcolm Turner, Richard J. Woodman, Emily M. Mulcahy, Sherin Vareeckal Joseph, Shweta Mhatre, Simon G. A. Brown, Michael D. Wiese, Nikolai Petrovsky, Robert J. Heddle, Pravin Hissaria   +14 more
wiley   +1 more source

Diverging in Vivo Immune Response Patterns After Oral Food Challenge in Peanut Allergic Adults

Clinical &Experimental Allergy, EarlyView.
After the oral food challenge, peanut (PN)‐allergic adults were monitored over 4 weeks, which revealed diverging immune response patterns, with strong responders (SR) exhibiting heightened Ara h 2+ B cell expansion, PN sIgE induction and increasing PN‐specific Tconv. Weak responders (WR) had more activated PN‐specific Tregs.
Florent Fauchère, Aikaterina Alexiou, Veronika Höfer, Kirsten Beyer, Sabine Dölle‐Bierke, Andreas Thiel, Margitta Worm, Julian Braun   +7 more
wiley   +1 more source

Proteotransciptomics of the Most Popular Host Sea Anemone Entacmaea quadricolor Reveals Not All Toxin Genes Expressed by Tentacles Are Recruited into Its Venom Arsenal

Toxins
While the unique symbiotic relationship between anemonefishes and sea anemones is iconic, it is still not fully understood how anemonefishes can withstand and thrive within the venomous environment of their host sea anemone.
Cassie M. Hoepner, Zachary K. Stewart, Robert Qiao, Emily K. Fobert, Peter J. Prentis, Alex Colella, Tim Chataway, Karen Burke da Silva, Catherine A. Abbott   +8 more
doaj   +1 more source