Results 241 to 250 of about 88,797 (311)

Peptide OH‐CATH30 Mitigates Cachexia‐Induced Muscle Atrophy via Modulation of TLR4‐Associated Inflammation

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Cachexia, characterized by severe weight loss and muscle atrophy, frequently occurs in chronic conditions such as sepsis, cancer and chemotherapy, with limited effective treatments. Despite similar clinical manifestations, the underlying mechanisms across different disease contexts remain unclear.
Qiquan Wang, Jian Li, Mengqi Yang, Caifen Guo, Ming Zhang, Chunping Huang, Xiang Wang, Dongqin Zhang, Lin Zeng, Hao Ke, Yunling Wen, Shengan Li, Wenhui Lee, Limin Zhao, Xinqiang Lan, Yang Xiang   +15 more
wiley   +1 more source

The many dimeric faces of Lys49 PLA2‐like proteins: Conformational plasticity and membrane binding drive functional dimer states

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Lys49 secreted phospholipase A2‐like proteins (sPLA2s) are major myotoxins in viperid snake venoms, causing rapid muscle damage in envenomation. Beyond their clinical relevance, these small non‐catalytic proteins provide a model to study how quaternary structure and conformational dynamics enable catalysis‐independent membrane disruption ...
Diane C. A. Lima, Vinicius Firmino dos Santos, Bernardo Rassi, Richard J. Ward, Thereza A. Soares   +4 more
wiley   +1 more source

Proteo-Transcriptomic Analysis of the Venom Gland of the Cone Snail <i>Cylinder canonicus</i> Reveals the Origin of the Predatory-Evoked Venom. [PDF]

Toxins (Basel)
Ratibou Z, Ebou AET, Bich C, Saintmont F, Valette G, Cazals G, Koua DK, Inguimbert N, Dutertre S.   +8 more
europepmc   +1 more source

ProteinDJ: A high‐performance and modular protein design pipeline

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Leveraging artificial intelligence and deep learning to generate proteins de novo (a.k.a. ‘synthetic proteins’) has unlocked new frontiers of protein design. Deep learning models trained on protein structures can generate novel protein designs that explore structural landscapes unseen by evolution.
Dylan Silke, Julie Iskander, Junqi Pan, Andrew P. Thompson, Anthony T. Papenfuss, Isabelle S. Lucet, Joshua M. Hardy   +6 more
wiley   +1 more source

<i>Micrurus nigrocinctus</i> in Colombia: Integrating Venomics Research, Citizen Science, and Community Empowerment. [PDF]

Toxins (Basel)
Rey-Suárez P, Rojo LP, Gómez-Robles J, Parra-Moreno S, Pachon-Camelo E, Fuentes-Florez Y, Lomonte B, Fernández J, Sasa M, Núñez V, Saldarriaga-Cordoba M.   +10 more
europepmc   +1 more source

Venoms, Venomous Animals, and Anti-venomous Serum-therapeutics

Nature, 1909
openaire   +2 more sources

Tackling High Dimensionality in QSP: Guiding Model Order Reduction With Index Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Quantitative systems pharmacology (QSP) models offer a useful platform to integrate drug pharmacology with knowledge about biological mechanisms across multiple scales and data sources into a unified quantitative framework. This makes them invaluable to address many relevant questions in drug research and development.
Johannes Tillil, Wilhelm Huisinga, Jane Knöchel   +2 more
wiley   +1 more source

Advances in Bioinspired Interfacial Adhesion with Frictional Enhancement: From Fundamental Research to Biomimetic Applications

Small Structures, Volume 7, Issue 2, February 2026.
Biological models in nature reveal remarkable friction‐adhesion mechanisms, driven by intermolecular forces and suction. Researchers leverage these principles to design advanced materials with enhanced adhesion properties. By optimizing these materials under stimuli like light and electricity, new solutions emerge for regulating interface interactions ...
Yunfang Sun, Xuemin Yang, Guang Liu, Liwen Zhang, Yue Fu, Ping Li, Weiteng Li, Guang Yang, Huanyu Cheng, Huawei Chen   +9 more
wiley   +1 more source

Hiss and tell: What influences venom yields of India's big four snakes? [PDF]

PLoS Negl Trop Dis
Gond PG, Kumar M, Unawane A, Sunagar K.
europepmc   +1 more source

The effect of fire ant (Hymenoptera: Formicidae) venom on ecologically relevant bacteria [PDF]

Ashley Morris, Robert Κ. Vander Meer, Roberto M. Pereira, Rebecca W. Baldwin, Satya P. Chinta   +4 more
openalex   +1 more source