Results 101 to 110 of about 53,540 (244)

A proteomics and transcriptomics investigation of the venom from the Barychelid spider Trittame loki (brush-foot trapdoor) [PDF]

, 2013
Although known for their potent venom and ability to prey upon both invertebrate and vertebrate species, the Barychelidae spider family has been entirely neglected by toxinologists. In striking contrast, the sister family Theraphosidae (commonly known as
Agostino Antunes, Alun Jones, Bryan Fry, Conesa, Dolyce Low, Eivind Undheim, Glenn King, Goldman, Herzig, Kartik Sunagar, Laurence Kely, Nielsen, Nyoman Kurniawan, Posada, Syed Ali, Tim Ruder, Timothy Jackson, Volker Herzig   +17 more
core   +3 more sources

Identification and Characterization of an In Silico Designed Membrane‐Active Peptide with Antiviral Properties

Advanced Science, EarlyView.
An evolutionary molecular dynamics platform is used to design P1.6, a membrane‐active peptide that senses lipid packing defects in viral envelopes. P1.6 adopts a stabilized α‐helical structure upon membrane contact, disrupts virus‐like liposomes, and damages HIV‐1 particles.
Pascal von Maltitz, Niek van Hilten, Tatjana Weil, Thunchanok Thummaraj, Jeroen Methorst, Dennis Aschmann, Alexander Kros, Clarissa Read, Jasmina Gačanin, Herre Jelger Risselada, Jan Münch   +10 more
wiley   +1 more source

Combating Antibiotic Resistance: Mechanisms, Multidrug-Resistant Pathogens, and Novel Therapeutic Approaches: An Updated Review

Pharmaceuticals
The escalating global health crisis of antibiotic resistance, driven by the rapid emergence of multidrug-resistant (MDR) bacterial pathogens, necessitates urgent and innovative countermeasures.
Mostafa E. Elshobary, Nadia K. Badawy, Yara Ashraf, Asmaa A. Zatioun, Hagar H. Masriya, Mohamed M. Ammar, Nourhan A. Mohamed, Sohaila Mourad, Abdelrahman M. Assy   +8 more
doaj   +1 more source

Ontogenetic Change in the Venom of Mexican Black-Tailed Rattlesnakes (Crotalus molossus nigrescens)

Toxins, 2018
Ontogenetic changes in venom composition have important ecological implications due the relevance of venom in prey acquisition and defense. Additionally, intraspecific venom variation has direct medical consequences for the treatment of snakebite ...
Miguel Borja, Edgar Neri-Castro, Rebeca Pérez-Morales, Jason L. Strickland, Roberto Ponce-López, Christopher L. Parkinson, Jorge Espinosa-Fematt, Jorge Sáenz-Mata, Esau Flores-Martínez, Alejandro Alagón, Gamaliel Castañeda-Gaytán   +10 more
doaj   +1 more source

Inflammasome Activation Induced by a Snake Venom Lys49-Phospholipase A2 Homologue [PDF]

, 2019
Charles Nunes Boeno, Mauro Valentino Paloschi, Jéssica Amaral Lopes, Weverson Luciano Pires, Sulamita da Silva Setúbal, Jaína Rodrigues Evangelista, Andreimar M. Soares, Juliana Pavan Zuliani   +7 more
openalex   +1 more source

Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage [PDF]

, 2015
20 páginas, 4 figuras, 3 tablas y 7 tablas en material suplementario.Snake venom hemorrhagic metalloproteinases (SVMPs) of the PI, PII and PIII classes were compared in terms of tissue localization and their ability to hydrolyze basement membrane ...
A Osaka, A Rucavado, A Rucavado, AF Pinto, AK Oliveira, Alexandra Rucavado, AM Moura-da-Silva, AM Moura-da-Silva, Ana Moura, BG Fry, C Baldo, Cristina Herrera, DB Gould, Diego Morazán, E Camacho, EN Baramova, EN Baramova, EN Baramova, J Durban, Jay W. Fox, JJ Calvete, JM Gutiérrez, JM Gutiérrez, JM Gutiérrez, JM Gutiérrez, José María Gutiérrez, Juan J. Calvete, JW Fox, Jéssica Kele A. Macêdo, K Kühn, K Kühn, L Watanabe, Libia Sanz, Mathieu-Benoit Voisin, N Jiménez, NR Casewell, NR Casewell, NR Casewell, PD Yurchenco, PD Yurchenco, R Timpl, SM Serrano, SM Serrano, SM Serrano, Sussan Nourshargh, SV Costes, T Escalante, T Escalante, T Escalante, T Nikai, Teresa Escalante, UK Laemmli, WJ Wang   +52 more
core   +4 more sources

Facile Access to Salt‐Resistant Polyzwitterionic Hydrogel Evaporator via In Situ Frontal Curing‐3D Printing Strategy

Advanced Science, EarlyView.
Polyzwitterionic hydrogel evaporator is developed by a facile in situ curing 3D printing strategy. It shows higher intermediate water/free water ratio in high‐salinity brine, leading to increased amount of activated water and lower evaporation enthalpy, which exhibits high evaporation efficiency and satisfactory salt tolerance.
Ya‐Lan Zhao, Jia‐Le Lu, Yong‐Chun Hou, Liangliang Zhu, Qing Li, Su Chen   +5 more
wiley   +1 more source

Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms

Toxins
Snakebite envenoming is a neglected tropical disease, responsible for approximately 140,000 deaths globally each year. Vipers and elapid snakes represent the most significant snake families in medical contexts, exhibiting a variety of venom components ...
Mahtab Khatibi, José R. Almeida, Soheil Gilabadi, David Ramírez, Paulina Valenzuela-Hormazábal, Ketan Patel, Sakthivel Vaiyapuri   +6 more
doaj   +1 more source

In vitro trichomonocidal potency of Naja nigricollis and Bitis arietans snake venom [PDF]

, 2021
Tijjani Sabiu Imam, Zainab Tukur, Aisha Abdullahi Bala, Nuraddeen Bello Ahmad, Adamu Yunusa Ugya   +4 more
openalex   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source