Results 101 to 110 of about 5,048,560 (285)

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Understanding ventilator-induced lung injury: The role of mechanical power.

Journal of critical care
Mechanical ventilation stands as a life-saving intervention in the management of respiratory failure. However, it carries the risk of ventilator-induced lung injury.
Stephan von Düring, K. Parhar, Neill K. J. Adhikari, M. Urner, S. J. Kim, L. Munshi, Kuan Liu, E. Fan   +7 more
semanticscholar   +1 more source

EGF RECEPTOR REGULATES MECHANICAL VENTILATION INDUCED LUNG INJURY IN MICE

Translational research : the journal of laboratory and clinical medicine, 2008
SUMMARY Mechanical ventilation (MV) is used as therapy to support critically ill patients, however the mechanisms by which MV induces lung injury and inflammation remain unclear.
Alexis Bierman, Adi Yerrapureddy, N. M. Reddy, P. Hassoun, S. Reddy   +4 more
semanticscholar   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Early changes in rat diaphragm biology with mechanical ventilation [PDF]

, 2003
To better characterize the effects of 24-hour mechanical ventilation on diaphragm, the expression of myogenic transcription factors, myosin heavy chains, and sarcoplasmic/endoplasmic reticulum calcium-ATPase pumps was examined in rats.
Decramer Marc, De Paepe, Kristel, Testelmans, Dries, Cadot Pascal, Gayan-Ramirez Ghislaine, Rácz, Gábor Z., Wuytack, Frank, Rácz Gábor Z., Zádor, Ernő, Decramer, Marc, Testelmans Dries, Paepe De Kristel, Cadot, Pascal, Zádor Ernő, Wuytack Frank, Gayan-Ramirez, Ghislaine   +15 more
core   +1 more source

Successful Use of Neurally Adjusted Ventilatory Assist in Managing Refractory Bilateral Pneumatoceles in a Premature Neonate

American Journal of Perinatology Reports
Background Pneumatoceles are air-filled cystic lesions within the lung parenchyma, often arising from severe pneumonia or mechanical ventilation-induced lung injury, which pose significant risk, particularly in neonates requiring high ...
Efren Diaz, Shamaila Gil, Lisa M. Scheid
doaj   +1 more source

High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study

BMC Anesthesiology, 2011
BackgroundTo examine whether acute lung injury from direct and indirect origins differ in susceptibility to ventilator-induced lung injury (VILI) and resultant systemic inflammatory responses.MethodsRats were challenged by acid instillation or 24 h of ...
J. Kuiper, F. Plötz, A. Groeneveld, J. Haitsma, S. Jothy, R. Vaschetto, Haibo Zhang, Arthur S Slutsky   +7 more
semanticscholar   +1 more source

Genome‐wide network analysis identifies the lncRNA‐92467/miR‐205‐5p/PTPRM/CAMs axis in a rat model of hypoxic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen, Yi‐Bing Chen, Xin Li, Xiang Xu, Ge Guo, Han‐Lu Li, Yong‐Ming Yao, Chun‐Lei Liu   +7 more
wiley   +1 more source

Bilateral phrenic nerve block to reduce hazardous respiratory drive in a mechanically ventilated patient with COVID‐19—A case report

Clinical Case Reports
Key Clinical Message Forced inspiration during mechanical ventilation risks self‐inflicted lung injury. However, controlling it with sedation or paralysis may cause polyneuropathy and myopathy.
Anja Levis, Michael Gardill, Kaspar F. Bachmann, David Berger, Christian Schandl, Lise Piquilloud, Matthias Haenggi   +6 more
doaj   +1 more source