Results 81 to 90 of about 5,048,560 (285)

Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation

Nature Communications, 2021
There are no targeted pharmacologic therapies to treat lung injury during mechanical ventilation (MV). Here the authors identify a mechanosensitive microRNA (miR-146a) in alveolar macrophages during MV and increase miR-146a to supraphysiological levels ...
Christopher M. Bobba, Qinqin Fei, Vasudha Shukla, Hyunwook Lee, Pragi Patel, Rachel K. Putman, Carleen Spitzer, MuChun Tsai, Mark D. Wewers, Robert J. Lee, John W. Christman, Megan N. Ballinger, Samir N. Ghadiali, Joshua A. Englert   +13 more
doaj   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Genetic targets of hydrogen sulfide in ventilator-induced lung injury--a microarray study. [PDF]

PLoS ONE, 2014
Recently, we have shown that inhalation of hydrogen sulfide (H2S) protects against ventilator-induced lung injury (VILI). In the present study, we aimed to determine the underlying molecular mechanisms of H2S-dependent lung protection by analyzing gene ...
Sashko Spassov, Dietmar Pfeifer, Karl Strosing, Stefan Ryter, Matthias Hummel, Simone Faller, Alexander Hoetzel   +6 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

An evaluation of the relative efficacy of an open airway, an oxygen reservoir and continuous positive airway pressure 5 cmH2O on the non-ventilated lung [PDF]

, 2004
Publisher's copy made available with the permission of the publisher © Australian Society of AnaesthetistsThe aim of this study, during one-lung ventilation, was to evaluate if oxygenation could be improved by use of a simple oxygen reservoir or ...
Russell, W., Jurisevic, C., Slimani, J.
core   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice

Pharmaceuticals, 2014
The mitochondrial targeted DNA repair enzyme, 8-oxoguanine DNA glycosylase 1, was previously reported to protect against mitochondrial DNA (mtDNA) damage and ventilator induced lung injury (VILI).
Masahiro Hashizume, Marc Mouner, Joshua M. Chouteau, Olena M. Gorodnya, Mykhaylo V. Ruchko, Glenn L. Wilson, Mark N. Gillespie, James C. Parker   +7 more
doaj   +1 more source

Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs

Respiratory Research, 2009
BackgroundBronchopulmonary dysplasia (BPD) is closely associated with ventilator-induced lung injury (VILI) in very preterm infants. The greatest risk of VILI may be in the immediate period after birth, when the lungs are surfactant deficient, still ...
M. Wallace, M. Probyn, V. Zahra, K. Crossley, T. Cole, P. Davis, C. Morley, S. Hooper   +7 more
semanticscholar   +1 more source

Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion

BMC Pulmonary Medicine, 2010
Background Ventilator-induced lung injury (VILI) is a recognized complication of mechanical ventilation. Although the specific mechanism by which mechanical ventilation causes lung injury remains an active area of study, the application of positive end ...
Altemeier William A, Polissar Nayak L, Sinclair Scott E   +2 more
doaj   +1 more source

Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway

Frontiers in Cell and Developmental Biology, 2020
BackgroundIn animal models of ventilation-induced lung injury, mitophagy triggers mitochondria damage and the release of mitochondrial (mt) DNA, which activates inflammation.
Ren Jing, Ren Jing, Zhao-Kun Hu, Zhao-Kun Hu, Fei Lin, Fei Lin, Sheng He, Sheng He, Sui-Sui Zhang, Sui-Sui Zhang, Wan-Yun Ge, Wan-Yun Ge, Hui-jun Dai, Hui-jun Dai, Xue-Ke Du, Xue-Ke Du, Jin-Yuan Lin, Jin-Yuan Lin, Ling-Hui Pan, Ling-Hui Pan   +19 more
doaj   +1 more source