Results 131 to 140 of about 2,969 (154)

Rocuronium exacerbates mechanical ventilation–induced diaphragm dysfunction in rats

Critical Care Medicine, 2006
Nondepolarizing neuromuscular blocking agents are commonly used in the intensive care setting, but they have occasionally been associated with development of myopathy. In addition, diaphragmatic atrophy and a reduction in diaphragmatic force were reported after short-term controlled mechanical ventilation in animal models. We hypothesized that infusion
Dries, Testelmans, Karen, Maes, Patrick, Wouters, Nadège, Gosselin, Keith, Deruisseau, Scott, Powers, Raf, Sciot, Marc, Decramer, Ghislaine, Gayan-Ramirez   +8 more
openaire   +2 more sources

Ventilator-induced diaphragm dysfunction: the clinical relevance of animal models

Intensive Care Medicine, 2007
Experimental evidence suggests that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called ventilator-induced diaphragmatic dysfunction (VIDD).
openaire   +2 more sources

Repeated exposure to heat stress results in a diaphragm phenotype that resists ventilator-induced diaphragm dysfunction

Journal of Applied Physiology, 2015
Controlled mechanical ventilation (CMV) is a life-saving intervention for patients in respiratory failure. Unfortunately, prolonged mechanical ventilation (MV) results in diaphragmatic atrophy and contractile dysfunction, both of which are predicted to contribute to problems in weaning patients from the ventilator.
Toshinori, Yoshihara, Noriko, Ichinoseki-Sekine, Ryo, Kakigi, Takamasa, Tsuzuki, Takao, Sugiura, Scott K, Powers, Hisashi, Naito   +6 more
openaire   +2 more sources

The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction

Science Translational Medicine, 2016
BGP-15 reduces ventilation-induced diaphragm dysfunction by improving diaphragm fiber and myosin function and enhancing mitochondrial activity.
Salah H, Li M, Cacciani N, Gastaldello S, Ogilvie H, Akkad H, Namuduri AV, Morbidoni V, Artemenko KA, Balogh G, Martinez-Redondo V, Jannig P, Hedström Y, Dworkin B, Bergquist J, Ruas J, Vigh L, Salviati L, Larsson L   +18 more
openaire   +4 more sources

Phrenic nerve stimulation protects against mechanical ventilation‐induced diaphragm dysfunction in rats

Muscle & Nerve, 2013
ABSTRACTIntroduction: We investigated a novel application of phrenic nerve stimulation (PNS) in diaphragm dysfunction induced by mechanical ventilation (MV). Methods: Twenty‐one Sprague‐Dawley rats were assigned randomly to 3 groups: spontaneous breathing, 18‐h controlled MV, and 18‐h controlled MV with PNS. Upon completion of the experimental protocol,
Meirong, Yang, Haitao, Wang, Guangwei, Han, Lianhua, Chen, Lina, Huang, Jihong, Jiang, Shitong, Li   +6 more
openaire   +2 more sources

[Ventilator-induced diaphragm dysfunction : clinically relevant problem].

Der Anaesthesist, 2015
Mechanical ventilation is a life-saving intervention for patients with respiratory failure or during deep sedation. During continuous mandatory ventilation the diaphragm remains inactive, which activates pathophysiological cascades leading to a loss of contractile force and muscle mass (collectively referred to as ventilator-induced diaphragm ...
C S, Bruells, G, Marx, R, Rossaint
openaire   +1 more source

Ventilator‐induced diaphragm dysfunction: phenomenology and mechanism(s) of pathogenesis

The Journal of Physiology
AbstractMechanical ventilation (MV) is used to support ventilation and pulmonary gas exchange in patients during critical illness and surgery. Although MV is a life‐saving intervention for patients in respiratory failure, an unintended side‐effect of MV is the rapid development of diaphragmatic atrophy and contractile dysfunction.
openaire   +2 more sources

Searching for the “Spark” in Ventilator-induced Diaphragm Dysfunction

American Journal of Respiratory and Critical Care Medicine, 2017
Claudia C, Dos Santos, Steven, Reynolds, Jane, Batt   +2 more
openaire   +2 more sources

Case Studies in Physiology: Physiological and clinical effects of temporary diaphragm pacing in two patients with ventilator-induced diaphragm dysfunction

Journal of Applied Physiology, 2021

exaly  

Suppression of Hypoxia-Inducible Factor 1α by Low-Molecular-Weight Heparin Mitigates Ventilation-Induced Diaphragm Dysfunction in a Murine Endotoxemia Model

International Journal of Molecular Sciences, 2021
Yung-Yang Liu, Li-Fu Li, Chih-Yu Huang   +2 more
exaly