Results 61 to 70 of about 3,855 (162)

Diaphragmatic function is enhanced in fatty and diabetic fatty rats. [PDF]

PLoS ONE, 2017
BACKGROUND:Obesity is associated with a decrease in mortality in the intensive care unit (ICU) (the "obesity paradox"). We hypothesized that obesity may paradoxically improve diaphragmatic function.
Audrey De Jong, Serge Carreira, Na Na, Aude Carillion, Cheng Jiang, Maud Beuvin, Jean-Marc Lacorte, Dominique Bonnefont-Rousselot, Bruno Riou, Catherine Coirault   +9 more
doaj   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Nivolumab-related myasthenia gravis with myositis requiring prolonged mechanical ventilation: a case report

Journal of Medical Case Reports, 2022
Background Nivolumab is an immune checkpoint inhibitor that blocks inhibitors of T-cell activation and blunts antitumor immunity and is used in the treatment of various cancers. However, immune checkpoint inhibitors have immune-related adverse effects on
Yumi Saishu, Takuya Yoshida, Yusuke Seino, Takeshi Nomura   +3 more
doaj   +1 more source

Obesity Hypoventilation Syndrome (OHS) as A Chronic Inflammatory Disease: A Clinical Case

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Delayed recognition and management of severe obesity and obesity hypoventilation syndrome may result in life‐threatening respiratory failure and multi‐organ complications requiring prolonged intensive care. In metabolically unstable patients, pre‐existing obesity‐related malnutrition may worsen despite obesity itself and contribute to ...
Sajedeh Zarghi, Samira Mawdoodi, Sara Movahed, Mohammad Safarian, Fatemeh Roudi   +4 more
wiley   +1 more source

Lung-protective ventilation worsens ventilator-induced diaphragm atrophy and weakness

Respiratory Research, 2020
Background Lung–protective ventilation (LPV) has been found to minimize the risk of ventilator–induced lung injury (VILI). However, whether LPV is able to diminish ventilator–induced diaphragm dysfunction (VIDD) remains unknown.
Xian-Long Zhou, Xiao-Jun Wei, Shao-Ping Li, Hao-Li Ma, Yan Zhao   +4 more
doaj   +1 more source

European Interdisciplinary Guidelines on Pain Management in Acute Pancreatitis: UEG, EPC, EDS, ESDO, EAGEN, ESPGHAN, ESGAR, and ESPCG Evidence‐Based Recommendations

United European Gastroenterology Journal, Volume 14, Issue 5, June 2026.
ABSTRACT Pain is often the presenting symptom of acute pancreatitis (AP) and has a prognostic significance, with poorly treated pain affecting patient outcomes. Despite this, there are currently no international recommendations for pain management in patients admitted with AP.
Sanjay Pandanaboyana, Cecilie Siggaard Knoph, Louise Kuhlmann, Patrice Forget, Esther Pogatzki‐Zahn, Wei Huang, Stefanos Bonovas, Daniele Piovani, Isabelle Scheers, Karina Cárdenas‐Jaén, Sara Regner, Asbjorn Mohr Drewes, on behalf of European Pain in Acute Pancreatitis Multidisciplinary Group, Maissam Abu‐El‐Haija, Jana Aulenkamp, Frank Bodewes, Stefan Bouwense, Roberto Cannella, Gabriele Capurso, Guralp Ceyhan, Enrique de‐Madaria, Sarah De Lucia, Ana Dugic, Ekin Demir, Enrique Domínguez‐Muñoz, Lucia Guilabert, Pramod Kumar Garg, Cheryl Hartzell, Peter Hegyi, Nejo Joseph, James Lucocq, Giovanni Marchegiani, Alessio Marchetti, Soeren Marsmann, Etna Masip, Vivek Peddakota, Manu Nayar, Sara Nikolic, Hanna Sternby, Jayanta Samanta, Sandeep Siddhi, Ajith Siriwardena, Vikesh Singh, Søren Schou Olesen, Grzegorz Oracz, Davor Stimac, Michael Wilschanski, Heiko Witt, John Windsor   +48 more
wiley   +1 more source

Evaluation of Ventilator-induced Diaphragmatic Dysfunction by Diaphragmatic Excursion During Spontaneous Breathing Trials

Journal of Anesthesia & Clinical Research, 2018
Introduction: Ventilator-induced diaphragmatic dysfunction (VIDD) leads to difficulties in weaning. Diaphragmatic excursion assessment by ultrasonography is a feasible bedside assessment of the diaphragm in the ICU. Our primary aim was to identify the presence of VIDD using US in patients undergoing Spontaneous breathing trials (SBT). Our secondary aim
Yasser Sadek Nassar, Mahmoud Elbanna, Moamen Arafa, Ashraf Hussein   +3 more
openaire   +1 more source

Association of diaphragmatic dysfunction with duration of mechanical ventilation in patients in the pediatric intensive care unit: a prospective cohort study

BMC Pediatrics
Background Mechanical ventilation (MV) can cause diaphragmatic injury and ventilator induced diaphragmatic dysfunction (VIDD). Diaphragm ultrasonography (DU) is increasingly used to assess diaphragmatic anatomy, function and pathology of patients ...
Yelin Yao, Xiaojing Guo, Yuxin Liu, Kai Lu, Weiming Chen, Huanhuan Yin, Guoping Lu, SuJuan Wang, Jinhao Tao   +8 more
doaj   +1 more source

Mechanical ventilation causes diaphragm dysfunction in newborn lambs

Critical Care, 2019
Background Diaphragm weakness occurs rapidly in adult animals treated with mechanical ventilation (MV), but the effects of MV on the neonatal diaphragm have not been determined.
Feng Liang, Guillaume Emeriaud, Dilson E. Rassier, Dong Shang, Ekaterina Gusev, Sabah N. A. Hussain, Michael Sage, Benjamin Crulli, Etienne Fortin-Pellerin, Jean-Paul Praud, Basil J. Petrof   +10 more
doaj   +1 more source

Severe, Non‐apneic Respiratory Dysfunction and Hypoxia following Generalized Convulsive Seizures

Annals of Neurology, Volume 99, Issue 5, Page 1263-1276, May 2026.
Objective Sudden unexpected death in epilepsy (SUDEP) is a devastating consequence of some generalized convulsive seizures (GCS). Recent work has focused on seizure related apnea as a biomarker of SUDEP risk, frequently without characterizing the adequacy of non‐apneic ventilation or identifying other dysfunctional breathing patterns.
Haley E. Pysick, Rup K. Sainju, Roshni Nair, Deidre N. Dragon, Eduardo Bravo, Laura Vilella, Xiaojin Li, Samden D. Lhatoo, George B. Richerson, Brian K. Gehlbach   +9 more
wiley   +1 more source