Results 41 to 50 of about 3,855 (162)

AGRN‐, LRP4‐, MUSK‐Related CMS: Clinical, Neurophysiological, Morphological, Genetic and Pathological Mechanisms

Muscle &Nerve, EarlyView.
ABSTRACT Congenital myasthenic syndromes (CMS) are inherited disorders caused by mutations in genes encoding proteins essential for neuromuscular junction (NMJ) function. Pathogenic variants have been identified in more than 35 genes, underscoring the complexity of synaptic biology and the wide range of mechanisms that can compromise neuromuscular ...
Rocio‐Nur Villar‐Quiles, Damien Sternberg, Marie‐Christine Nougues, Arnaud Isapof, Bruno Eymard, Stéphanie Bauché   +5 more
wiley   +1 more source

Recent Advances in Pediatric Ventilatory Assistance [version 1; referees: 2 approved]

F1000Research, 2017
In this review on respiratory assistance, we aim to discuss the following recent advances: the optimization and customization of mechanical ventilation, the use of high-frequency oscillatory ventilation, and the role of noninvasive ventilation.
Nicolas Nardi, Guillaume Mortamet, Laurence Ducharme-Crevier, Guillaume Emeriaud, Philippe Jouvet   +4 more
doaj   +1 more source

A 4D geometric morphometrics workflow to quantify complex biological motion

Methods in Ecology and Evolution, EarlyView.
Abstract Quantifying biological motion is fundamentally tied to quantifying the biological structures that produce that motion. Yet, this dependence makes it essential to decouple motion from static morphology to enable general, comparable analyses across individuals and conditions. In this work, we present a methodological pipeline to study biological
Marta Gómez‐Recio, Markus Bastir, Gael Deboeck, Antonella LoMauro, Andrea Aliverti, Véronique Feipel, Barbara Fischer, Philipp Mitteroecker, Benoit Beyer   +8 more
wiley   +1 more source

Effect of Long-Term Polytrauma on Ventilator-Induced Diaphragmatic Dysfunction in a Piglet Model [PDF]

Shock, 2019
ABSTRACT Introduction: Mechanical ventilation is known to activate oxidative stress and proteolytic pathways in the diaphragm. Trauma by inducing inflammation and activating proteolytic pathways may potentiate the effects of mechanical ventilation on the diaphragm.
Breuer, Thomas, Bruells, Christian S., Horst, Klemens, Thiele, Christoph, Hildebrand, Frank, Linnartz, Stephan, Siegberg, Tom, Frank, Nadine, Gayan-Ramirez, Ghislaine, Martin, Lukas, Ostareck, Dirk H., Marx, Gernot, Simon, Tim-Philipp   +12 more
openaire   +3 more sources

Sugammadex vs. neostigmine and the risk of postoperative pulmonary complications after upper gastrointestinal endoscopic procedures: a propensity score matched analysis of 15,730 patients

Anaesthesia, EarlyView.
Summary Introduction Postoperative pulmonary complications after upper gastrointestinal endoscopic procedures under general anaesthesia are clinically important and may be exacerbated by residual neuromuscular block. We evaluated whether antagonism of neuromuscular block with sugammadex rather than neostigmine is associated with improved respiratory ...
Yung‐Fong Tsai, Kuo‐Chuan Hung, Chih‐Yi Hsu, Huan‐Tang Lin, Yi‐Chen Lai, Shao‐Chun Wu   +5 more
wiley   +1 more source

Catheter Ablation: Evolution and Efficiencies

Journal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT The present review includes a discussion the goals and pitfalls of efficiency in the medical profession, a historical perspective on the evolution of catheter ablation in the field of electrophysiology (EP), and the data regarding the relationship between efficiency and outcomes in the EP lab. Focus on efficacy is critical to maximize resource
Aravind G. Kalluri, Bradley P. Knight
wiley   +1 more source

Temporary transvenous diaphragm pacing vs. standard of care for weaning from mechanical ventilation: study protocol for a randomized trial

Trials, 2019
Background Mechanical ventilation (MV) is a life-saving technology that restores or assists breathing. Like any treatment, MV has side effects. In some patients it can cause diaphragmatic atrophy, injury, and dysfunction (ventilator-induced diaphragmatic
Douglas Evans, Deborah Shure, Linda Clark, Gerard J. Criner, Martin Dres, Marcelo Gama de Abreu, Franco Laghi, David McDonagh, Basil Petrof, Teresa Nelson, Thomas Similowski   +10 more
doaj   +1 more source

Early rehabilitation relieves diaphragm dysfunction induced by prolonged mechanical ventilation: a randomised control study

BMC Pulmonary Medicine, 2021
Background Prolonged mechanical ventilation (MV) induces diaphragm dysfunction in patients in the intensive care units (ICUs). Our study aimed to explore the therapeutic efficacy of early rehabilitation therapy in patients with prolonged MV in the ICU ...
Zehua Dong, Ying Liu, Yubiao Gai, Pingping Meng, Hui Lin, Yuxiao Zhao, Jinyan Xing   +6 more
doaj   +1 more source

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Ventilator-induced diaphragm dysfunction: translational mechanisms lead to therapeutical alternatives in the critically ill

Intensive Care Medicine Experimental, 2019
Mechanical ventilation [MV] is a life-saving technique delivered to critically ill patients incapable of adequately ventilating and/or oxygenating due to respiratory or other disease processes.
Oscar Peñuelas, Elena Keough, Lucía López-Rodríguez, Demetrio Carriedo, Gesly Gonçalves, Esther Barreiro, José Ángel Lorente   +6 more
doaj   +1 more source