Results 31 to 40 of about 3,855 (162)

Ventilator-induced diaphragmatic dysfunction

Current Opinion in Critical Care, 2010
Diaphragmatic function is a major determinant of the ability to successfully wean patients from mechanical ventilation. There is increasing recognition of a condition termed ventilator-induced diaphragmatic dysfunction. The purpose of the present review is to present evidence that mechanical ventilation can itself be a cause of diaphragmatic ...
Petrof, Basil, Jaber, Samir, Matecki, Stefan   +2 more
openaire   +3 more sources

[Ventilator-induced diaphragmatic dysfunction].

Revista chilena de pediatria, 2016
The ventilator-induced diaphragmatic dysfunction is a group of disorders caused by the inactivity of the diaphragm muscle during controlled mechanical ventilation. From a structural point of view, the diaphragm subjected to mechanical ventilation undergoes an atrophy process, in which decreased synthesis and increased muscle protein degradation are ...
Jorge, Valenzuela V, Ramón, Pinochet U, Máximo, Escobar C, José Luis, Márquez A, Raquel, Riquelme V, Pablo, Cruces R   +5 more
openaire   +4 more sources

Angiotensin 1‐7 protects against ventilator‐induced diaphragm dysfunction

Clinical and Translational Science, 2021
Mechanical ventilation (MV) is a life‐saving instrument used to provide ventilatory support for critically ill patients and patients undergoing surgery.
Toshinori Yoshihara, Rafael Deminice, Hayden W. Hyatt, Mustafa Ozdemir, Branden L. Nguyen, Scott K. Powers   +5 more
doaj   +1 more source

Mechanical ventilation induces diaphragmatic mitochondrial dysfunction and increased oxidant production [PDF]

Free Radical Biology and Medicine, 2009
Mechanical ventilation (MV) is a life-saving intervention used in patients with acute respiratory failure. Unfortunately, prolonged MV results in diaphragmatic weakness, which is an important contributor to the failure to wean patients from MV. Our laboratory has previously shown that reactive oxygen species (ROS) play a critical role in mediating ...
Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA ( host institution ), Kavazis, Andreas N. ( author ), Talbert, Erin E. ( author ), Smuder, Ashley J. ( author ), Hudson, Matthew B. ( author ), Nelson, W. Bradley ( author ), Powers, Scott K. ( author )   +6 more
openaire   +3 more sources

Comparative Efficacy of Angiotensin II Type 1 Receptor Blockers Against Ventilator‐Induced Diaphragm Dysfunction in Rats

Clinical and Translational Science, 2021
Mechanical ventilation (MV) is a life‐saving intervention for many critically ill patients. Unfortunately, prolonged MV results in the rapid development of inspiratory muscle weakness due to diaphragmatic atrophy and contractile dysfunction (termed ...
Stephanie E. Hall, Bumsoo Ahn, Ashley J. Smuder, Aaron B. Morton, J. Matthew Hinkley, Michael P. Wiggs, Kurt J. Sollanek, Hayden Hyatt, Scott K. Powers   +8 more
doaj   +1 more source

Calpains play an essential role in mechanical ventilation-induced diaphragmatic weakness and mitochondrial dysfunction

Redox Biology, 2021
Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, an unintended consequence of prolonged MV is the rapid development of diaphragmatic atrophy and contractile dysfunction, known as ventilator ...
Hayden W. Hyatt, Mustafa Ozdemir, Toshinori Yoshihara, Branden L. Nguyen, Rafael Deminice, Scott K. Powers   +5 more
doaj   +1 more source

Impact of cumulative steroid therapy dose on ultrasonography-assessed diaphragmatic functions in critically ill mechanically ventilated pediatric patients: a prospective observational study

Alexandria Journal of Medicine
Background Corticosteroids are widely used in critical care settings for different indications. Their use is associated with steroid-induced myopathy that can affect the diaphragm.
Marwan M. Fahim, Ahmed A. El-Nawawy, Azza A. A. Moustafa, Hadir M. Hassouna   +3 more
doaj   +1 more source

Ultrasound assessment of diaphragmatic dysfunction in non-critically ill patients: relevant indicators and update

Frontiers in Medicine
Diaphragm dysfunction (DD) can be classified as mild, resulting in diaphragmatic weakness, or severe, resulting in diaphragmatic paralysis. Various factors such as prolonged mechanical ventilation, surgical trauma, and inflammation can cause ...
Xin-Yu Yao, Xin-Yu Yao, Hong-Mei Li, Hong-Mei Li, Bo-Wen Sun, Bo-Wen Sun, Ying-Ying Zhang, Ying-Ying Zhang, Jian-Guo Feng, Jian-Guo Feng, Jing Jia, Jing Jia, Li Liu, Li Liu   +13 more
doaj   +1 more source

Diaphragm ultrasound as a new functional and morphological index of outcome, prognosis and discontinuation from mechanical ventilation in critically ill patients and evaluating the possible protective indices against VIDD

Egyptian Journal of Chest Disease and Tuberculosis, 2017
Background: There is increasing awareness that diaphragm weakness is common in patients undergoing MV and is likely a contributing cause of weaning failure.
Eman Ramzy Ali, Ahmad Mostafa Mohamad
doaj   +1 more source

Phrenic nerve stimulation prevents diaphragm atrophy in patients with respiratory failure on mechanical ventilation

BMC Pulmonary Medicine, 2021
Background Diaphragm atrophy and dysfunction is a major problem among critically ill patients on mechanical ventilation. Ventilator-induced diaphragmatic dysfunction is thought to play a major role, resulting in a failure of weaning.
Michal Soták, Karel Roubík, Tomáš Henlín, Tomáš Tyll   +3 more
doaj   +1 more source