Results 101 to 110 of about 4,770,227 (251)

Targeting eEF1A1 With Baicalein to Block eEF1A1/Prdx4 Interaction for Treating Sepsis‐Mediated Lung Injury

Exploration, EarlyView.
Targeting eEF1A1 with baicalein disrupts the eEF1A1‐Prdx4 interaction to prevent RNF14‐mediated ubiquitination and degradation of Prdx4. This stabilizes Prdx4 to suppress NF‐κB, thereby alleviating sepsis‐induced acute lung injury. ABSTRACT Sepsis is a systemic inflammatory response syndrome triggered by an uncontrolled host response to infection ...
Jing Chang, Hui‐Lin Zhang, Qi‐Meng Zhu, Si‐Wen Hui, Xin‐Rong Xu, Mahmood Brobbey Oppong, Yan‐Li Feng, Juan Zhang, Cheng‐Peng Sun, Feng Qiu   +9 more
wiley   +1 more source

Monitoring and assessment for obstructive sleep apnea

FlexMat, EarlyView.
This review systematically classifies Obstructive Sleep Apnea (OSA) monitoring indicators into three categories: physical, biochemical, and electrophysiological indicators, and lists several methods for each category. Abstract Obstructive sleep apnea (OSA) is a common chronic sleep‐disordered breathing disease characterized by recurrent upper airway ...
Yaowen Xu, Feifei Lin, Shujiao Chen, Zhen You, Shujing Zhu, Weiwei Zhao, Qiang Zhao   +6 more
wiley   +1 more source

Early Inflammation Mainly Affects Normally and Poorly Aerated Lung in Experimental Ventilator-Induced Lung Injury*

, 2014
OBJECTIVE: The common denominator in most forms of ventilator-induced lung injury is an intense inflammatory response mediated by neutrophils. PET with [F]fluoro-2-deoxy-D-glucose can be used to image cellular metabolism, which, during lung inflammatory ...
Costa, Eduardo L V, Göran Hedenstierna, Suarez-Sipmann, Fernando,, Eduardo L. V. Costa, Widström, Charles,, João Batista Borges, Hedenstierna, Göran,, Borges, João Batista,, Larsson, Anders,, Marcelo Amato, Amato, Marcelo, Anders Larsson, Charles Widström, Fernando Suarez-Sipmann   +13 more
core   +1 more source

Safety and Metabolic Effects of Withania somnifera Seed Extract and Powder in Rats: Insights From DPP‐4 Molecular Docking

Food Safety and Health, EarlyView.
Withania somnifera seed extract and powder improved metabolic parameters in rats, particularly at higher extract doses, without evident hepatic, renal, hematological, or histopathological toxicity. Molecular docking further predicted strong DPP‐4 inhibitory potential of withanone, supporting the antidiabetic potential of W. somnifera seeds.
Muhammad Usman Khalid, Muhammad Waqar, Muhammad Tauseef Sultan, Muhammad Maaz, Ahmad Mujtaba Noman, Hassan Raza, Muhammad Israr, Djilali Benabdelmoumene, Abdifetah Ibrahim Omar   +8 more
wiley   +1 more source

Ventilator-induced lung injury

, 2014
To the Editor: Slutsky and Ranieri (Nov. 28 issue)(1) note that ventilator-induced lung injury may be minimized by means of lung-protective mechanical ventilation or by avoiding it altogether with the use of extracorporeal life-support techniques(2) such
Shekar, Kiran, Fraser, John F.
core  

Strain threshold for ventilator-induced lung injury

, 2011
Introduction Unphysiological lung strain (tidal volume/functional residual capacity, TV/FRC) may cause ventilator-induced lung injury (VILI) [1]. Whether VILI develops proportionally to the applied strain or only above a critical threshold remains ...
T Langer, G Conte, A Santini, D. Febres, L. Lombardi, A Protti, M. Cressoni Mainoni, G. Conte, T. Langer, P. Taccone, D Febres, P Taccone, A. Protti, M. Lattuada, M Lattuada, L Gattinoni, M Cressoni, L Lombardi, A. Santini, L. Gattinoni   +19 more
core   +1 more source

Animal model of unilateral ventilator-induced lung injury

, 2005
Objective To design, implement, and test a selective lung ventilator for setting a rat model of unilateral ventilator-induced lung injury (VILI).
Farre, Ramon, Rotger, Mar, Granell, Susana, Closa, Daniel, Serrano-Mollar, Anna, Navajas, Daniel   +5 more
core   +1 more source

Bidirectional pressure: a mini review of ventilator-lung-kidney interactions

Frontiers in Physiology
Acute kidney injury and respiratory failure that requires mechanical ventilation are both common complications of critical illnesses. Failure of either of these organ systems also increases the risk of failure to the other.
Avnee Kumar, Avnee Kumar, Katie Epler, Katie Epler, Sean DeWolf, Sean DeWolf, Laura Barnes, Laura Barnes, Mark Hepokoski, Mark Hepokoski   +9 more
doaj   +1 more source

Monocyte inflammation and adaptive immune dysfunction in severe Klebsiella pneumoniae pneumonia

iMeta, EarlyView.
Severe Klebsiella pneumoniae pneumonia combines intense inflammation with failure to control infection, yet the cellular basis is unclear. Using a severity‐focused single‐cell atlas of 708,894 peripheral blood mononuclear cells from 100 individuals, complemented by plasma protein measurements and flow cytometry, we show that disease severity redirects ...
Hongquan Chen, Xiaoling Wang, Xiang Liu, Kui Dong, Yanying Feng, Min Yuan, Shiyi Wang, Fangfang Fan, Yong Tian, Zhiming Kang, Xiushuai Du, Chaolu Hasi, Hong Lu, Wei Guan, Xu Chen, Mengyu Cheng, Wei Wei, Nan Guo, Zhiguo Liu, Xiaotong Qiu, Yiwei Shi, Kun Xiao, Yi Wang, Zhenjun Li   +23 more
wiley   +1 more source

Compare Serum VCAM‐1, NSE, Procalcitonin in Predict Sepsis Induced Encephalopathy in Septic Patients

Journal of Clinical Laboratory Analysis, EarlyView.
Serum VCAM‐1 is associated with septic encephalopathy in the first 7 days of sepsis. NSE and procalcitonin were not associated with septic encephalopathy. ABSTRACT Background Sepsis‐associated encephalopathy (SAE) is a common complication of severe sepsis. Increased concentration of Vascular Cell Adhesion Molecule 1 (VCAM‐1) is associated with SAE in a
Chun‐Fu Lin, Cheng‐Hsien Lu, Chih‐Min Su   +2 more
wiley   +1 more source