Results 111 to 120 of about 4,770,227 (251)

Prone position delays the progression of ventilator-induced lung injury in rats : Does lung strain distribution play a role?

, 2005
Objective: To investigate if prone position delays the progression of experimental ventilator-induced lung injury, possibly due to a more homogeneous distribution of strain within lung parenchyma.
E. Carlesso, M. Guglielmi, C. Tedesco, M. Lazzerini, P. Maccagni, G. Aletti, N. Carboni, M. Irace, G. A. Porro, F. Valenza, T. Fossali, L. Gattinoni, M. Maffioletti   +12 more
core   +1 more source

Unfractionated Heparin and Low‐Molecular‐Weight Heparin in Sepsis: Anti‐Inflammatory and Anticoagulant Effects Versus No Anticoagulation—A Propensity Score‐Matched Analysis

Journal of Clinical Laboratory Analysis, EarlyView.
This propensity score‐matched study compared unfractionated heparin (UFH) and low‐molecular‐weight heparin (LMWH) in 1362 sepsis patients, finding that both significantly improved survival without increasing 90‐day bleeding risk. However, their therapeutic mechanisms differed: UFH demonstrated broader anti‐inflammatory effects by reducing IL‐6, IL‐8 ...
Peili Chen, Yi Yao, Bing Zhao, Yuan An, Jian Jiang, Li Ma, Enqiang Mao, Yihui Wang   +7 more
wiley   +1 more source

Protective Ventilation vs. Hypercapnia for the Attenuation of Ventilator-Associated Lung Injury

, 2011
Mechanically ventilated patients are at risk of developing Ventilator-Associated Lung Injury (VALI). Improved ventilation strategies by lung-protective settings may cause hypercapnia.
Ismaiel, Nada
core  

Diaphragm Ultrasonography Reveals Progressive Changes in Diaphragmatic Function, Morphology, and Muscle Trophism During Invasive Mechanical Ventilation in Children

Journal of Clinical Ultrasound, EarlyView.
Diaphragm ultrasonography detected progressive structural and functional deterioration in mechanically ventilated children. Prolonged invasive mechanical ventilation and neuromuscular blocking agent use were associated with ventilator‐induced diaphragmatic dysfunction, highlighting ultrasound as a valuable bedside tool to support individualized ...
Juliana Bezerra dos Santos, Emmerson Carlos Franco de Farias, Mary Lucy Ferraz Maia Fiuza de Mello, Rodrigo Santiago Barbosa Rocha   +3 more
wiley   +1 more source

Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury

, 2012
Lung inflammatory responses in the absence of infection are considered to be one of primary mechanisms of ventilator-induced lung injury. Here, we determined the role of calpain in the pathogenesis of lung inflammation attributable to mechanical ...
Zhibo Yan, David E. Schwartz, Guochang Hu, Yuguo Chen, Dejie Liu, Richard D. Minshall   +5 more
core   +1 more source

Overview of ventilator-induced lung injury mechanisms

, 2005
PURPOSE OF REVIEW: Mechanical ventilation is the main supportive therapy for patients with acute respiratory distress syndrome. As with any therapy, mechanical ventilation has side effects and may induce lung injury.
RECCHIA FA, RANIERI VM, LIONETTI V
core   +2 more sources

Food Security Versus Environmental Health: The Nitrogen Dilemma

Journal of Plant Nutrition and Soil Science, EarlyView.
ABSTRACT Nitrogen is an essential element for plant growth and, consequently, crop production. However, the cycling of nitrogen in the environment can have negative effects. Here, we review the historical development of scientific and public awareness of these effects and the influence this has had on political action to control them.
Henrike Mielenz, Norbert Bischoff, Klaus Butterbach‐Bahl, Uwe Häußermann, Kurt‐Christian Kersebaum, Karin Rather, Burkhard Stever‐Schoo, Reinhard Well, Claas Nendel   +8 more
wiley   +1 more source

Chronic, Environmentally Relevant PM2.5 Exposure Exacerbates Metabolic Dysfunction‐Associated Steatotic Liver Disease and Early‐Stage Renal Dysfunction in a Rodent Model

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT While epidemiological studies link fine particulate matter (PM2.5) exposure to metabolic dysfunction‐associated steatotic liver disease (MASLD) and renal dysfunction, a translational gap exists, as most animal models utilize acute, high‐dose exposures that poorly reflect chronic, moderate‐level human scenarios.
Yi‐Siao Chen, Hugo You‐Hsien Lin, Chien‐Tzu Lin, Si‐Hua Huang, Ming‐Lun Yeh, Ming‐Lung Yu, Jin‐Ching Lee, Yao‐Chi Chung, Wei‐Ming Li, Ching‐Chia Li, Shiu‐Feng Huang, Chia‐Hung Yen   +11 more
wiley   +1 more source

Kaempferol Attenuates Myocardial Ischemia–Reperfusion Injury by Suppressing Ferroptosis via the KEAP1–Nrf2–GPX4 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao, Ling‐Ling Sun, Xiao‐Hua Shen, Min Wang, Mei‐Hui Wang, Lu‐Lu Liu, Kai Zhang   +6 more
wiley   +1 more source

Ventilator-associated lung injury

, 2013
Mechanical ventilation of disease-affected lungs, as well as being an inadequate mode of ventilation for initially healthy lungs, can cause significant changes in their structure and function. In order to differentiate these processes, two terms are used:
Maciejewski, Dariusz; Department of Anaesthesiology and Intensive Therapy, District Hospital in Bielsko-Biała, Poland Chair of Nursing and Emergency Medicine, Faculty of Health Sciences, Technical-Humanistic Academy, Bielsko-Biała, Poland, Kuchnicka, Katarzyna   +1 more
core   +1 more source