Results 81 to 90 of about 4,770,227 (251)

Three‐dimensional geometric morphometric analysis of diaphragmatic dome motion in COPD patients

The Anatomical Record, EarlyView.
Abstract Diaphragmatic dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD), especially in emphysema, where hyperinflation alters diaphragm geometry and impairs inspiratory mechanics. However, quantitative three‐dimensional (3D) assessments of diaphragmatic dome shape and motion across COPD phenotypes are limited.
José M. López‐Rey, Benoît Beyer, Elena García‐Vargas, Isabel Torres‐Sánchez, Francisco García‐Río, Markus Bastir   +5 more
wiley   +1 more source

Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat [PDF]

, 2012
The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Paulus, Patrick, Tacke Sabine, Johannes Holfeld, Karnowski Nora, Patrick Paulus, Holfeld, Johannes, Urbschat, Anja, Urbschat Anja, Zacharowski, Kai, Tacke, Sabine, Ockelmann, Pia, Nora Karnowski, Karnowski, Nora, Bertram Scheller, Scheller, Bertram, Pia Ockelmann, Ellinghaus, Peter, Paulus Patrick, Zacharowski Kai, Sabine Tacke, Ellinghaus Peter, Anja Urbschat, Kai Zacharowski, Peter Ellinghaus, Ockelmann Pia, Scheller Bertram, Holfeld Johannes   +26 more
core   +2 more sources

Lung injury promoted by strong inspiratory efforts and breath stacking: impact of ventilation mode

Intensive Care Medicine Experimental
Background Breath stacking, particularly double triggering, is a common patient–ventilator asynchrony during strong inspiratory effort. It can cause excessive tidal volumes and high transpulmonary pressures, contributing to ventilator-induced lung injury
Yasuhiro Norisue, Sunao Usami, Yukie Ito, Muneyuki Takeuchi, Atsushi Kawamura, Ryuichi Nakayama, Naofumi Bunya, Jun Kataoka, Yusuke Endo, Takaharu Itami, Taku Hirokawa, Chihiro Sugita, Hirotaka Takeshima, Airi Takemoto, Miyako Kyogoku, Junki Koike, Shigeki Fujitani, Francesco Mojoli, Taku Miyasho   +18 more
doaj   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Heparin-binding protein in ventilator-induced lung injury

Intensive Care Medicine Experimental, 2018
Background Although mechanical ventilation is often lifesaving, it can also cause injury to the lungs. The lung injury is caused by not only high pressure and mechanical forces but also by inflammatory processes that are not fully understood.
Jonas Tydén, N. Larsson, S. Lehtipalo, H. Herwald, M. Hultin, J. Walldén, A. F. Behndig, J. Johansson   +7 more
doaj   +1 more source

Dose‐related propofol resistance in COVID‐19 patients: Altered drug plasma levels, mechanistic insights from neuronal‐derived extracellular vesicles and miRNA analysis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Critical care for COVID‐19 patients presents unique challenges, particularly in sedation management. Patients demonstrate notable dose‐related resistance to propofol, potentially due to complex pharmacokinetic alterations. Emerging evidence suggests that plasma extracellular vesicle‐associated miRNA represents valuable predictive ...
Debora Curci, Carlotta Bidoli, Marco Gerdol, Charisse Winston, Robert A. Rissman, Giuliana Decorti, Antonella Fabretto, Andrea Taddio, Gabriele Stocco, Erik Roman‐Pognuz, Marianna Lucafò   +10 more
wiley   +1 more source

Lung purinoceptor activation triggers ventilator-induced brain injury [PDF]

, 2019
OBJECTIVES: Mechanical ventilation can cause ventilator-induced brain injury via afferent vagal signaling and hippocampal neurotransmitter imbalances. The triggering mechanisms for vagal signaling during mechanical ventilation are unknown.
Thoralf Niendorf, López-Alonso, I., Niendorf, T., Francis, R.C.E., Reimann, H., Kuebler, W., Pickerodt, P.A., Wolfgang Kuebler, Roland C.E. Francis, Claudia D. Spies, Laura Amado-Rodríguez, Spies, C.D., Clarissa von Haefen, Guillermo M. Albaiceta, von Haefen, C., Philipp A. Pickerodt, Albaiceta, G.M., Henning Reimann, Amado-Rodríguez, L., Adrian González-López, González-López, A., Ines López-Alonso   +21 more
core   +1 more source

Bilateral phrenic nerve block to reduce hazardous respiratory drive in a mechanically ventilated patient with COVID‐19—A case report

Clinical Case Reports
Key Clinical Message Forced inspiration during mechanical ventilation risks self‐inflicted lung injury. However, controlling it with sedation or paralysis may cause polyneuropathy and myopathy.
Anja Levis, Michael Gardill, Kaspar F. Bachmann, David Berger, Christian Schandl, Lise Piquilloud, Matthias Haenggi   +6 more
doaj   +1 more source

Compliant hydrogel cuff coating with real‐time pressure monitoring and antibiofilm capabilities for ventilator‐associated pneumonia prophylaxis

BMEMat, EarlyView.
A soft‐compliant hydrogel cuff coating combines real‐time pressure monitoring with intrinsic antibacterial activity for prophylaxis of ventilator‐associated pneumonia. A flexible pressure‐sensing patch is embedded in the coating to enable wireless dynamic monitoring of endotracheal cuff pressure through Bluetooth.
Jin Chai, Yifu Tan, Jiaheng Liang, Shen Liu, Jiabin Zhao, Shanbo Ma, Chunxin Liu, Minghua Du, Mark Selvan, Xiaopeng Shi, Liqiang Song, Peng Li   +11 more
wiley   +1 more source

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis   +12 more
wiley   +1 more source