Results 71 to 80 of about 4,770,227 (251)

Динаміка показників легеневого ушкодження за умови експериментального HCl-індукованого гострого ураження легень = Dynamics of pulmonary damage parameters in experimental HCl-induced acute lung injury [PDF]

, 2014
Hryshchuk L. A., Besky V. O., Marushchak M. I. Динаміка показників легеневого ушкодження за умови експериментального HCl-індукованого гострого ураження легень = Dynamics of pulmonary damage parameters in experimental HCl-induced acute lung injury ...
Besky, V. O., Hryshchuk, L. A., Marushchak, M. I.   +2 more
core   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Acute lung inflammation and ventilator-induced lung injury caused by ATP via the P2Y receptors: an experimental study

Respiratory Research, 2008
Background Extracellular adenosine 5'-triphosphate (ATP) is an endogenous signaling molecule involved in multiple biological phenomena, including inflammation. The effects of extracellular ATP in the lung have not been fully clarified.
Shime Nobuaki, Mizuta Mitsuhiko, Beppu Satoru, Ueno Hiroshi, Hashimoto Soshi, Amaya Fumimasa, Matsuyama Hiroki, Ishizaka Akitoshi, Hashimoto Satoru   +8 more
doaj   +1 more source

Ventilator dyssynchrony – Detection, pathophysiology, and clinical relevance: A Narrative review

Annals of Thoracic Medicine, 2020
Mortality associated with the acute respiratory distress syndrome remains unacceptably high due in part to ventilator-induced lung injury (VILI). Ventilator dyssynchrony is defined as the inappropriate timing and delivery of a mechanical breath in ...
Peter D Sottile, David Albers, Bradford J Smith, Marc M Moss   +3 more
doaj   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Effects of body temperature on ventilator-induced lung injury

, 2005
Purpose: To evaluate the effects of body temperature on ventilator-induced lung ...
Turkoz, KH, Kiran, BAYRAM, Yilmazbayhan, D, Celik, M, Tugrul, S, Telci, Lütfü, Ozcan, Perihan, Akinci, Ozan, Martino, JM, Yeldandi, AV, Cakar, Nahit, Mutlu, GM   +11 more
core   +1 more source

The neuronal guidance protein netrin-1 reduces alveolar inflammation in a porcine model of acute lung injury [PDF]

, 2010
Introduction: Acute lung injury (ALI) is an inflammatory disorder of pulmonary or extrapulmonary origin. We have previously demonstrated that netrin-1 dampens murine ALI, and in an attempt to advance this finding into future clinical practice we ...
Kristina Waibler, Gabriele Nöldge-Schomburg, Rosenberger, Peter, Dierk A Vagts, Peter Rosenberger, Vagts, Dierk A., Klemens König, Thomas Iber, Christian Mutz, Westermann, Phillipp, Nöldge-Schomburg, Gabriele, Mutz, Christian, König, Klemens, Iber, Thomas, Valbona Mirakaj, Mirakaj, Valbona, Phillipp Westermann, Waibler, Kristina   +17 more
core   +1 more source

Genome‐wide network analysis identifies the lncRNA‐92467/miR‐205‐5p/PTPRM/CAMs axis in a rat model of hypoxic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen, Yi‐Bing Chen, Xin Li, Xiang Xu, Ge Guo, Han‐Lu Li, Yong‐Ming Yao, Chun‐Lei Liu   +7 more
wiley   +1 more source