Results 61 to 70 of about 4,770,227 (251)

Dexmedetomidine alleviates lung tissue injury of rat models with ventilator-associated lung injury [PDF]

Jichu yixue yu linchuang
Objective To investigate the effect of dexmedetom idine (DEX) on lung tissue and Ras homolog gene family member A (RhoA)/Rho kinase 1 (ROCK1) signaling pathway in lung tissue of rats with ventilator-induced lung injury (VILI).
HAN Huijing, WU Hong, GE Yin, QIAO Juan
doaj   +1 more source

Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs

Nature Communications, 2020
Preclinical studies have shown that negative pressure ventilation ex situ lung perfusion results in less ventilator-induced lung injury compared to positive pressure ventilation of donor lungs during transplantation procedures. Here the authors perform a
Max T. Buchko, Nasim Boroumand, Jeffrey C. Cheng, Alim Hirji, Kieran Halloran, Darren H. Freed, Jayan Nagendran   +6 more
doaj   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury [PDF]

, 2005
RATIONALE: Mechanical ventilation with high VT (HVT) progressively leads to lung injury and decreased efficiency of gas exchange. Hypoxic pulmonary vasoconstriction (HPV) directs blood flow to well-ventilated lung regions, preserving systemic oxygenation
R. Liu, Caironi, Pietro, R. C. Jones, P. Caironi, F. Ichinose, K. D. Bloch, W. M. Zapol   +6 more
core   +1 more source

Experimental Models of Acute Lung Injury to Study Inflammation and Pathophysiology: A Narrative Review

Antioxidants
Acute lung injury (ALI) is characterized by acute respiratory insufficiency, including tachypnea, cyanosis refractory to oxygen, decreased lung compliance, and diffuse alveolar infiltrates, which is a condition associated with high morbidity and ...
Akinori Cardozo Nagato, Pedro Alves Machado-Junior, Samuel Santos Valenca, Remo Castro Russo, Frank Silva Bezerra   +4 more
doaj   +1 more source

A role for bronchial epithelial autotaxin in ventilator-induced lung injury

Intensive Care Medicine Experimental, 2021
Background The pathophysiology of acute respiratory distress syndrome (ARDS) may eventually result in heterogeneous lung collapse and edema-flooded airways, predisposing the lung to progressive tissue damage known as ventilator-induced lung injury (VILI).
Ioanna Nikitopoulou, Ioanna Ninou, Nikolaos Manitsopoulos, Ioanna Dimopoulou, Stylianos E. Orfanos, Vassilis Aidinis, Anastasia Kotanidou   +6 more
doaj   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

Lung anatomy, energy load, and ventilator-induced lung injury [PDF]

, 2015
High tidal volume can cause ventilator-induced lung injury (VILI), but positive end-expiratory pressure (PEEP) is thought to be protective.
E. Carlesso, VOTTA, EMILIANO, L. Lombardi, Comini, Beatrice, D.T. Andreis, E. Votta, Eleonora Carlesso, Santini, Alessandro, Monti, Massimo, B. Comini, Beatrice Comini, Andreis, Davide T, Iapichino, Giacomo E, Lombardi, Luciano, Melis, Valentina, Pugni, Paola, Emiliano Votta, Gatti, Stefano, Carlesso, Eleonora, A. Santini, S. Gatti, Paola Pugni, V. Melis, Milesi, Marta, Gattinoni, Luciano, Daniele Dondossola, Stefano Gatti, Marta Milesi, M. Monti, Luciano Lombardi, Giacomo E. Iapichino, G. E. Iapichino, P. Pugni, D. Dondossola, Valentina Melis, Alessandro Santini, A. Protti, Luciano Gattinoni, Protti, Alessandro, Davide T. Andreis, M. Milesi, Dondossola, Daniele, Massimo Monti, Alessandro Protti, L. Gattinoni   +44 more
core   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source