Ferritinophagy mediated by the AMPK/ULK1 pathway is involved in ferroptosis subsequent to ventilator-induced lung injury. [PDF]
Ou H +10 more
europepmc +1 more source
Lung‐Cardiovascular Interactions and Derangements in ARDS
This review proposes an anatomical near‐ and far‐field framework for lung‐cardiovascular interactions in ARDS. Grounded in pathological and biological studies, the evidence spans pulmonary vascular, right ventricular, and systemic endothelial derangements and reviews available evidence for targeted therapies.
Pablo A. Sanchez +4 more
wiley +1 more source
Ventilator induced lung injury: a case for a larger umbrella? [PDF]
Gattinoni L, Collino F, Camporota L.
europepmc +1 more source
Pulmonary hypertension is driven by dynamic crosstalk beyond the physical connection between the heart and lung, involving neurohormonal systems, immune pathways, and peripheral organs. This review highlights how multisystem signaling contributes to disease progression and may reveal new diagnostic and therapeutic targets.
Alejandro A. Vega +4 more
wiley +1 more source
MiR-125b-5p ameliorates ventilator-induced lung injury in rats by suppressing ferroptosis via the regulation of the Keap1/Nrf2/GPX4 signaling pathway. [PDF]
Zhang J +12 more
europepmc +1 more source
Axial Connectivity of the Lung Microbiome: A Review of Interorgan Crosstalk
The human microbiome mediates immune homeostasis and metabolic signaling across organs. Beyond the gut‐lung axis, crosstalk between the lung and other organ systems is less recognized. This review assesses the axial connectivity of the lung microbiome across the gut, brain, skin, heart, kidney, and liver.
Mathangi Palanivel +2 more
wiley +1 more source
Correction: Mechanical power ratio threshold for ventilator-induced lung injury. [PDF]
D'Albo R +17 more
europepmc +1 more source
In this study, we found that sinensetin can effectively inhibit the inflammatory response and damage of lung cells caused by LPS in vivo and in vitro. This might be caused by the action of sinensetin in regulating the HIF‐1α‐MAPK signaling cascade.
Zuomin Hu +9 more
wiley +1 more source
Emerging roles of mechanosensitive ion channels in ventilator induced lung injury: a systematic review. [PDF]
Liu G +4 more
europepmc +1 more source
Post‐Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management
A comprehensive review on post‐tuberculosis lung disease (PTLD) addresses the epidemiology, pathogenesis, clinical phenotypes and management, risk factors, prevention and systems approach, and future directions. This review provides standardized definitions, mechanistic insights and biomarkers of PTLD development, and clinical strategies for PTLD ...
Radha Gopalaswamy, Selvakumar Subbian
wiley +1 more source

