Results 221 to 230 of about 4,770,227 (251)

Inhibition of leucine‐rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation‐network remodelling

British Journal of Pharmacology, Volume 183, Issue 20, Page 6199-6224, October 2026.
Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang, Eun Mo Yang, Gil Song, Seung Min Park, Harryn Choi, Jaeyong Kim, Chanil Kim, Yunho Gim, Hyuk‐Joo Jeon, Yewon Cho, Jong Bae Park, Eun‐Mi Hur   +11 more
wiley   +1 more source

IFITM3 Is Elevated in BAL and Plasma Following Infection in ICU Setting

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
IFITM3 levels in BAL and plasma of critically ill patients. ABSTRACT Interferon‐induced transmembrane protein 3 (IFITM3) is an antiviral protein with emerging roles in regulating inflammatory pathways. Although much is known about the role of IFITM3 in mediating host antiviral defense, its contribution to systemic immune responses during critical ...
Srabani Das, Carleen R. Spitzer, Paul Consiglio, Matthew C. Exline, Anasuya Sarkar   +4 more
wiley   +1 more source

How to Prevent Ventilator-Induced Lung Injury in Intraoperative Mechanical Ventilation? A Randomized Prospective Study. [PDF]

Turk J Anaesthesiol Reanim
Türk M, Tontu F, Aşar S, Saygı Emir N, Hergünsel GO.   +4 more
europepmc   +1 more source

Bio‐Inspired Biopolymeric Implantable Platform for Localized and Sustained Drug Delivery in Solid Tumor Treatment

Advanced Functional Materials, Volume 36, Issue 73, 10 September 2026.
A bio‐inspired biopolymeric implantable drug delivery platform enables localized and sustained release of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38) in solid tumor treatment. The three‐dimensional (3D) structured crosslinked‐chitosan implants are fabricated via 3D‐printed molds and provide drug release over 3 months, significantly inhibiting tumor growth ...
Mercedes Lozano‐Garcia, Constantine Vogiatzis, Alejandra Planells‐Devesa, Emre Dikici, Caroline Vieira Maluf, Vasudev Vivekanand Nayak, Paulo G. Coelho, Lukasz Witek, Alicia Bilbao, Daniel Bilbao, Prasoon Mohan, Sapna Deo, Sylvia Daunert   +12 more
wiley   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

A machine-learning regional clustering approach to understand ventilator-induced lung injury: a proof-of-concept experimental study. [PDF]

Intensive Care Med Exp
Cruces P, Retamal J, Damián A, Lago G, Blasina F, Oviedo V, Medina T, Pérez A, Vaamonde L, Dapueto R, González-Dambrauskas S, Serra A, Monteverde-Fernandez N, Namías M, Martínez J, Hurtado DE.   +15 more
europepmc   +1 more source

Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury: an experimental study. [PDF]

Intensive Care Med Exp
Liggieri F, Chiodaroli E, Pellegrini M, Puuvuori E, Sigfridsson J, Velikyan I, Chiumello D, Ball L, Pelosi P, Stramaglia S, Antoni G, Eriksson O, Perchiazzi G.   +12 more
europepmc   +1 more source

Capsaicin mitigates ventilator-induced lung injury by suppressing ferroptosis and maintaining mitochondrial redox homeostasis through SIRT3-dependent mechanisms. [PDF]

Mol Med
Lin J, Ou H, Luo B, Ling M, Lin F, Cen L, Hu Z, Ye L, Pan L.   +8 more
europepmc   +1 more source