Results 121 to 130 of about 16,700 (245)

Influence of inspiratory muscle training on weaning patients from mechanical ventilation: a systematic review

Fisioterapia em Movimento
Introduction: The inability of respiratory muscles to generate force and endurance is recognized as an important cause of failure in weaning patients from invasive mechanical ventilation (IMV).
Márcia Souza Volpe, Andrezza Aparecida Aleixo, Pedro Rodrigo Magalhães Negreiros de Almeida   +2 more
doaj   +1 more source

Early Isoflurane Exposure Is Associated With Delayed Adolescent Neurobehavioral Deficits, Accompanied by Dysregulation of FOXG1 and EB3

Developmental Neurobiology, Volume 86, Issue 3, July 2026.
ABSTRACT Early‐life exposure to general anesthetics has been linked to long‐term neurodevelopmental risks, yet the underlying mechanisms remain unclear. Using a mouse model, we show that neonatal isoflurane exposure at Postnatal Day 7 leads to age‐dependent behavioral alterations, changes in cortical neuronal abundance and layer‐specific neuronal ...
Ke Chen, Mengdi Xia, Changhong Li, Zhenhua Ren, Xiaohui Li   +4 more
wiley   +1 more source

An algorithm for discontinuing mechanical ventilation in boys with x-linked myotubular myopathy after positive response to gene therapy: the ASPIRO experience

Respiratory Research
X-linked myotubular myopathy (XLMTM) is a rare, life-threatening congenital myopathy. Most (80%) children with XLMTM have profound muscle weakness and hypotonia at birth resulting in severe respiratory insufficiency, the inability to sit up, stand or ...
Robert J. Graham, Reshma Amin, Nadir Demirel, Lisa Edel, Charlotte Lilien, Victoria MacBean, Gerrard F. Rafferty, Hemant Sawnani, Carola Schön, Barbara K. Smith, Faiza Syed, Micaela Sarazen, Suyash Prasad, Salvador Rico, Geovanny F. Perez   +14 more
doaj   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Congenital Myopathies and Muscular Dystrophies: A Single Tertiary Center Experience and Factors Associated With Long‐Term Outcomes

Muscle &Nerve, Volume 74, Issue 1, Page 121-130, July 2026.
ABSTRACT Introduction/Aims Data on respiratory, feeding, ambulatory outcomes and prognostic factors for congenital myopathies (CM) and congenital muscular dystrophies (CMD) remain limited. Therefore, in this study, we report the characteristics of a large single‐center cohort of patients with CM and CMD, focusing on long‐term outcomes and aiming to ...
Can Ozlu, Margaret McGurn, Susan Iannaccone, Zurisadai Gonzalez Castillo, Kaitlin Batley   +4 more
wiley   +1 more source

Cognitive Rehabilitation Interventions in the Intensive Care Unit: A Systematic Integrative Review

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Because critical illness, sedation, and ICU treatment commonly disrupt attention, memory, and executive function, early cognitive rehabilitation during the ICU stay may preserve or restore these capacities, reduce the delirium burden, and support engagement and recovery.
Kamila C. Lassen, Eva Laerkner, Janet F. Jensen, Ingrid Egerod, Jan Christensen, Kasper Jørgensen, Rikke S. Kjærgaard, Sepideh Olausson, Hilde Wøien, Anne H. Nielsen, Maj‐Brit N. Kjær, Camilla R. L. Bruun, Hejdi Gamst‐Jensen, Anders Perner, Marie O. Collet   +14 more
wiley   +1 more source

Psychological ventilator dependence: A case report [PDF]

, 2015
Weaning a patient off mechanical ventilation, especially when they have been dependent on it for a long time, can be a difficult task. Many physical and psychological factors contribute towards dependence on the ventilator. We re-.
Nilesh Shah, Avinash De, Harshal Sathe, Dr Avinash De Sousa, Sousa ), Avinash De Sousa   +5 more
core  

Early Versus Late Wake‐Up Call After Out‐Of‐Hospital Cardiac Arrest: Protocol for a Multicenter Randomized Comparison Within the Danish Out‐of‐Hospital Cardiac Arrest (DANOHCA) Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Survivors of out‐of‐hospital cardiac arrest (OHCA) who remain comatose after return of spontaneous circulation are routinely sedated and mechanically ventilated during early post‐resuscitation care. Although prolonged sedation has traditionally been considered necessary, contemporary normothermia‐based temperature control allows ...
Anders Morten Grejs, Jesper Kjaergaard, Jo Bønding Andreasen, Bodil Steen Rasmussen, Christian Hassager, Martin Abild Stengaard Meyer, Lars Peter Kloster Andersen, Henrik Schmidt, Simon Moelstroem, Sören Möller, Christhopher Torp, Steffen Christensen, Jacob Eifer Moeller   +12 more
wiley   +1 more source

Change of Heart Rate Variability during Ventilator Weaning

, 2009
Study objectives: Despite the recognition that ventilator weaning is associated with a change in autonomic nervous system activity, there has not been any report concerning the change of heart rate variability (HRV), a reliable method to detect autonomic
沈修年;林亮宇;陳冠宇;郭炳宏;余忠仁;吳惠東;楊泮池, SHEN, HSIU-NIEN;LIN, LIAN-YU;CHEN, KUAN -YU;KUO, PING-HUNG;YU, CHONG-JEN;WU, HUEY-DONG;YANG, PAN-CHYR   +1 more
core  

Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE‐MAKE): A Protocol for a Pre‐Planned Sub‐Study of a Randomized Clinical Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 6, July 2026.
ABSTRACT Background Acute kidney injury (AKI) is a common and serious complication after cardiac arrest, affecting more than 30% of initially successfully resuscitated patients, with around 10% receiving Kidney Replacement Therapy (KRT). Currently, treatment options to prevent renal complications are limited.
Keski‐Keturi M, Niemelä V.H, Young P, Nielsen N, Wise M.P, Reinikainen M, Bass F, Lilja G, Dankiewicz J, Hammond N, Hästbacka J, Levin H, Moseby‐Knappe M, Saxena M, Tiainen M, Ceric A, Kamp C.B, Sillassen C.D.B, Alexandersson D, Schmidbauer S, Tirkkonen J, Oksanen T, Säkkinen H, Bendel S, Düring J, Lybeck A, Johnsson J, Unden J, Lundin A, Kåhlin J, Grip J, Lotman E, Romundstad L, Seidel P, Stammet P, Graf T, Mengel A, Leithner C, Nee J, Druwé P, Ameloot K, McGuigan P.J, White J, Govier M, Ostermann M, Hopkins P, Proudfoot A, Handslip R, Pogson D, Jackson P, Nichol A, Haenggi M, Hilty M.P, Iten M, Schrag C, Nafi M, Joannidis M, Robba C, Belohlavek J, Rob D, Arabi Y, Al‐Fares A, Yew Woon C, Aneman A, Stewart A, Arnott C, Ramanan M, Panwar R, Delaney A, Reade M, Venkatesh B, Taccone F, Pekkarinen P.T, Friberg H, Cronberg T, Jakobsen J.C, Skrifvars M.B   +76 more
wiley   +1 more source