Results 41 to 50 of about 293,543 (262)

A Novel Mixed Finite/Infinite Dimensional Port–Hamiltonian Model of a Mechanical Ventilator

Computation
Mechanical ventilation is a life-saving treatment for critically ill patients who are struggling to breathe independently due to injury or disease. Globally, per year, there has always been a large number of individuals who have required mechanical ...
Milka C. I. Madahana, John E. D. Ekoru, Otis T. C. Nyandoro   +2 more
doaj   +1 more source

Improving mechanical ventilation for patient care through repetitive control [PDF]

arXiv, 2020
Mechanical ventilators sustain life of patients that are unable to breathe (sufficiently) on their own. The aim of this paper is to improve pressure tracking performance of mechanical ventilators for a wide variety of sedated patients. This is achieved by utilizing the repetitive nature of sedated ventilation through repetitive control.
arxiv  

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Conventional Mechanical Ventilation

Saudi Journal of Anaesthesia, 2010
The provision of mechanical ventilation for the support of infants and children with respiratory failure or insufficiency is one of the most common techniques that are performed in the Pediatric Intensive Care Unit (PICU). Despite its widespread application in the PICUs of the 21st century, before the 1930s, respiratory failure was uniformly fatal due ...
openaire   +4 more sources

Complications of mechanical ventilation

Srpski arhiv za celokupno lekarstvo, 2011
Mechanical ventilation of the lungs, as an important therapeutic measure, cannot be avoided in critically ill patients. However, when machines take over some of vital functions there is always a risk of complications and accidents. Complications associated with mechanical ventilation can be divided into: 1) airway-associated complications ...
Goran Rakic, Biljana Draskovic
openaire   +4 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Patient-Ventilator Dyssynchrony [PDF]

Korean Journal of Critical Care Medicine, 2017
In mechanically ventilated patients, assisted mechanical ventilation (MV) is employed early, following the acute phase of critical illness, in order to eliminate the detrimental effects of controlled MV, most notably the development of ventilator-induced
Elvira-Markela Antonogiannaki, Dimitris Georgopoulos, Evangelia Akoumianaki   +2 more
doaj   +1 more source

Air–Oxygen Blenders for Mechanical Ventilators: A Literature Review

Sensors, 2022
Respiratory diseases are one of the most common causes of death in the world and this recent COVID-19 pandemic is a key example. Problems such as infections, in general, affect many people and depending on the form of transmission they can spread ...
Gabryel F. Soares, Otacílio M. Almeida, José W. M. Menezes, Sergei S. A. Kozlov, Joel J. P. C. Rodrigues   +4 more
doaj   +1 more source

Optimal ventilation rate for effective displacement ventilation [PDF]

arXiv, 2021
Indoor ventilation is essential for a healthy and comfortable living environment. A key issue is to discharge anthropogenic air contamination such as CO2 gas or, more seriously, airborne respiratory droplets. Here, by employing direct numerical simulations, we study the mechanical displacement ventilation with the realistic range of air changes per ...
arxiv