Results 161 to 170 of about 313,250 (274)

Deletion of the sodium leak channel NALCN in dopamine neurons alters D2R‐mediated signalling and psychostimulant responsiveness

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The sodium leak channel NALCN is an important contributor to the spontaneous pacemaker activity of midbrain dopamine neurons and is required for proper presynaptic D2 autoreceptor signalling at dopaminergic terminals. Conditional deletion of NALCN in dopamine neurons enhances psychomotor sensitization to amphetamine and cocaine ...
Angelina Rogliardo   +16 more
wiley   +1 more source

Molecular Control of Neural Stem Cell Quiescence in the Adult Zebrafish Telencephalon: Established Mechanisms and an Integrative Hypothesis

open access: yesGlia, Volume 74, Issue 12, December 2026.
Adult zebrafish radial glia quiescence is controlled by at least four mechanisms: Notch3, BMP‐Id1, Nr2f1b and Midkine‐a. We propose these act as partially redundant inputs, biased along the antero‐posterior axis that set quiescence depth. ABSTRACT The zebrafish telencephalon is an excellent model for adult neurogenesis under physiological and ...
Mathilde Hoareau   +2 more
wiley   +1 more source

Mechanisms of Exercise Training in Ameliorating Cognitive Function in Patients With Depression: A Narrative Review of Molecular Targets and Clinical Prescriptions

open access: yesEuropean Journal of Sport Science, Volume 26, Issue 11, November 2026.
ABSTRACT Depression is frequently accompanied by core cognitive impairments, notably in executive function and memory. Although the ameliorative effects of exercise training have been widely corroborated, the evidence regarding its underlying mechanisms remains fragmented. To provide a comprehensive and integrated view, this review proposes a testable,
Zhaohui Guo   +17 more
wiley   +1 more source

Pathogenic Variants in HEPACAM Alter Protein Localization and Interactome in Astrocytes of the Developing Mouse Cortex

open access: yesGlia, Volume 74, Issue 11, November 2026.
Pathogenic variants alter hepaCAM protein distribution. Astrocyte‐specific hepaCAM TurboID reveals KCNQ2 as a new interaction partner. Pathogenic variants alter hepaCAM association with key transmembrane proteins. ABSTRACT Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy characterized by early‐onset macrocephaly,
Robert W. Lewis   +10 more
wiley   +1 more source

Aberrant salience is selectively associated with ventral midbrain connectivity to the dorsal but not ventral striatum. [PDF]

open access: yesSchizophrenia (Heidelb)
Li Y   +11 more
europepmc   +1 more source

Temporal Interference Modulates Medial Temporal and Frontoparietal Activity During Mnemonic Discrimination: A High‐Resolution Whole‐Brain fMRI Investigation

open access: yesHippocampus, Volume 36, Issue 6, November 2026.
ABSTRACT Mnemonic discrimination—the ability to distinguish between existing memories and similar new inputs—supports accurate memory in the face of interference (e.g., in a card game, recognizing that the card you are currently seeing, the King of Hearts, is distinct from the King of Diamonds you encountered earlier in the same hand).
Min Sung Seo   +4 more
wiley   +1 more source

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